A Decision-Support System to Personalize Antidepressant Treatment in Major Depressive Disorder: A Randomized Clinical Trial.
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| Title: | A Decision-Support System to Personalize Antidepressant Treatment in Major Depressive Disorder: A Randomized Clinical Trial. |
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| Authors: | Cipriani A; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England.; NIHR Oxford Health Clinical Research Facility, Oxford Health NHS Foundation Trust, Oxford, England., Fernandes KBP; School of Medicine, Pontifícia Universidade Católica do Paraná, Londrina, Brazil.; Graduate Program of Health Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil., Mulsant BH; Department of Psychiatry, Temerty School of Medicine, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada.; Royal Ottawa Hospital, Ottawa, Ontario, Canada., Efthimiou O; Institute of Primary Health Care, University of Bern, Bern, Switzerland.; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland., Williams N; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England., Mort S; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England., Elgarf R; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England., Liu Q; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England.; School of Engineering, Mathematics, and Technology, University of Bristol, Bristol, England., Haque N; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England., Potts J; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England., Ede R; NIHR Oxford Health Clinical Research Facility, Oxford Health NHS Foundation Trust, Oxford, England., Fox R; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England., Liboni M; Health Sciences Center, Londrina State University, Londrina, Brazil., Nesi Cavicchioli DA; Health Sciences Center, Londrina State University, Londrina, Brazil., Simon J; Department of Psychiatry, University of Oxford, Oxford, England.; Department of Health Economics, Medical University of Vienna, Vienna, Austria., Smith KA; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England.; NIHR Oxford Health Clinical Research Facility, Oxford Health NHS Foundation Trust, Oxford, England., Zangani C; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England.; NIHR Oxford Health Clinical Research Facility, Oxford Health NHS Foundation Trust, Oxford, England., Li Z; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England., Taylor U; NIHR South Central Regional Research Delivery Network, Southampton, England., Husain MI; Department of Psychiatry, Temerty School of Medicine, University of Toronto, Toronto, Ontario, Canada.; Centre for Addiction and Mental Health, Toronto, Ontario, Canada., Cipriani M; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts., Carpaneze Dalaqua PV; School of Medicine, Pontifícia Universidade Católica do Paraná, Londrina, Brazil., Leite EF; Health Sciences Center, Londrina State University, Londrina, Brazil., Aliano Gâmbaro G; School of Medicine, Pontifícia Universidade Católica do Paraná, Londrina, Brazil.; Graduate Program of Health Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil., Nabhan Silveira D; School of Medicine, Pontifícia Universidade Católica do Paraná, Londrina, Brazil., Manfredin Vila L; Health Sciences Center, Londrina State University, Londrina, Brazil., Liboni Cavicchioli F; School of Medicine, Pontifícia Universidade Católica do Paraná, Londrina, Brazil., Furukawa TA; Office of Institutional Advancement and Communications, Kyoto University, Kyoto, Japan., Naci H; Department of Health Policy, London School of Economics and Political Science, London, England., Ostinelli EG; Department of Psychiatry, University of Oxford, Oxford, England.; Oxford Precision Psychiatry Lab, NIHR Oxford Health Biomedical Research Centre, Oxford, England. |
| Corporate Authors: | PETRUSHKA Team |
| Source: | JAMA [JAMA] 2026 Apr 14; Vol. 335 (14), pp. 1219-1231. |
| Publication Type: | Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: American Medical Association Country of Publication: United States NLM ID: 7501160 Publication Model: Print Cited Medium: Internet ISSN: 1538-3598 (Electronic) Linking ISSN: 00987484 NLM ISO Abbreviation: JAMA Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1538-3598 |
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| DOI: | 10.1001/jama.2026.1327 |
