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Drug screening on tumor organoids exposes therapeutic vulnerabilities of meningiomas to HDAC1/2i panobinostat.

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Title: Drug screening on tumor organoids exposes therapeutic vulnerabilities of meningiomas to HDAC1/2i panobinostat.
Authors: Jungwirth G; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK) Core-Center Heidelberg, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Cao J; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Pan Y; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Warta R; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Lotsch C; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Moustafa M; German Cancer Consortium (DKTK) Core-Center Heidelberg, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD), Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Clinical Pathology, Suez Canal University, 41522 Ismailia, Egypt., Knoll M; German Cancer Consortium (DKTK) Core-Center Heidelberg, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD), Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Department of Radiation Oncology and Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany., Yu T; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Braun V; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Jassowicz L; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Trong PD; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Wang Z; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Younsi A; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Scherer M; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Bendszus M; Department of Neuroradiology, Heidelberg University, 69120 Heidelberg, Germany., Krieg SM; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., von Deimling A; Department of Neuropathology, Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology (B300), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Debus J; Department of Radiation Oncology and Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital (UKHD), 69120 Heidelberg, Germany.; Clinical Cooperation Radiation Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany., Abdollahi A; German Cancer Consortium (DKTK) Core-Center Heidelberg, Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Oncology (NCRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, Heidelberg Faculty of Medicine (MFHD), Heidelberg University Hospital (UKHD), Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.; Clinical Cooperation Unit Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital (UKHD) and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Unterberg A; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany., Sahm F; Department of Neuropathology, Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany.; Clinical Cooperation Unit Neuropathology (B300), German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany., Herold-Mende C; Division of Experimental Neurosurgery, Department of Neurosurgery, Heidelberg University, 69120 Heidelberg, Germany.
Source: Science translational medicine [Sci Transl Med] 2026 Mar 04; Vol. 18 (839), pp. eaea3115. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1946-6242
DOI:10.1126/scitranslmed.aea3115