DysUFMylation reprograms immunosuppressive neutrophils to potentiate anti-PD-1 therapy in hepatocellular carcinoma.

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Title: DysUFMylation reprograms immunosuppressive neutrophils to potentiate anti-PD-1 therapy in hepatocellular carcinoma.
Authors: Gao X; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China., Xu M; Department of Thoracic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, PR China., Han Z; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China., Hu Z; Institute of Fudan Minhang Academic Health System, Minhang Hospital, Fudan University, Shanghai, 201100, PR China., Su Y; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China., Sun G; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China., Chen W; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China., Qiu S; Shanghai Key Laboratory of Multidimensional Information Processing, East China Normal University, Shanghai, 200241, PR China., Qiu S; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China., Hung MC; Graduate Institute of Biomedical Sciences and Center for Molecular Medicine, China Medical University, Taichung, Taiwan, 40402. Electronic address: mhung@cmu.edu.cn., Zhou C; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China. Electronic address: zhouchenhao@fudan.edu.cn., Yi Y; Department of Hepatobiliary Surgery and Liver Transplantation, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, 200032, PR China. Electronic address: yi.yong@zs-hospital.sh.cn.
Source: Cancer letters [Cancer Lett] 2026 May 01; Vol. 645, pp. 218395. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1872-7980
DOI:10.1016/j.canlet.2026.218395