Personalized pharmacokinetic-pharmacodynamic guided therapy via an induced pluripotent stem cell-derived multi-organoid platform in NF1-mutant breast cancer.
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| Title: | Personalized pharmacokinetic-pharmacodynamic guided therapy via an induced pluripotent stem cell-derived multi-organoid platform in NF1-mutant breast cancer. |
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| Authors: | Lim JH; Disease modeling and therapeutics team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.; Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Mun SJ; Liver organoid team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea., Kang HM; Disease modeling and therapeutics team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.; Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Yu WD; Korea University of Science and Technology (UST), Daejeon, Republic of Korea.; Intestine organoid team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea., Oh SJ; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.; Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Lee JY; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea., Son YS; Intestine organoid team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea., Lee S; Korea University of Science and Technology (UST), Daejeon, Republic of Korea.; Digital Biotech Innovation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea., Kim DS; Korea University of Science and Technology (UST), Daejeon, Republic of Korea.; Digital Biotech Innovation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea., Lee J; Liver organoid team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea., Kim SJ; Disease modeling and therapeutics team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea.; Korea University of Science and Technology (UST), Daejeon, Republic of Korea., Cho HS; Disease modeling and therapeutics team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea. chohs@kribb.re.kr.; Korea University of Science and Technology (UST), Daejeon, Republic of Korea. chohs@kribb.re.kr., Son MJ; Korea University of Science and Technology (UST), Daejeon, Republic of Korea. mjson@kribb.re.kr.; Liver organoid team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea. mjson@kribb.re.kr., Son MY; Korea University of Science and Technology (UST), Daejeon, Republic of Korea. myson@kribb.re.kr.; Intestine organoid team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea. myson@kribb.re.kr., Jung CR; Disease modeling and therapeutics team, Stem cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of Korea. crjung@kribb.re.kr.; Korea University of Science and Technology (UST), Daejeon, Republic of Korea. crjung@kribb.re.kr. |
| Source: | Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Mar 05; Vol. 11 (1). Date of Electronic Publication: 2026 Mar 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2059-3635 |
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| DOI: | 10.1038/s41392-026-02595-7 |
