FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation.
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| Title: | FBXO39 knockdown promotes spermatogenesis impairment by inducing mitochondrial dysfunction and ferroptosis via inhibiting KDM5A ubiquitination and regulating H3K4me3 demethylation. |
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| Authors: | Li T; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Wang K; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Chen Y; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Li Z; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Li S; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Zhang Y; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Zhu X; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Shi H; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Gao L; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China., Jiang H; The Department of Kidney Transplantation, The Second Affiliated Hospital of Hainan Medical University, 368 Yehai Road, Longhua District, Haikou City, 570216, Hainan Province, China. jht20032003@163.com. |
| Source: | Cell biology and toxicology [Cell Biol Toxicol] 2026 Mar 04; Vol. 42 (1). Date of Electronic Publication: 2026 Mar 04. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Switzerland NLM ID: 8506639 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6822 (Electronic) Linking ISSN: 07422091 NLM ISO Abbreviation: Cell Biol Toxicol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1573-6822 |
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| DOI: | 10.1007/s10565-026-10167-2 |
