Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.

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Title: Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.
Authors: Yao ZG; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Department of Pathology, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China., Li XL; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Wen WJ; Department of Pathology, Liaocheng People's Hospital, Liaocheng, 252000, Shandong, China., Lin XY; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Zhang GH; Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong, China., Sun YP; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Nie YC; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Zheng ZM; Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Xu YQ; Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China., Yang M; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Yu TF; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Dong Y; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Hou YH; Department of Pathology and Center for Molecular Medicine Testing, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.; Department of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Dang LL; Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China., Chu SG; Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China., Li JM; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Ma JW; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Wang Z; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Hua F; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, China. fanghua09@hotmail.com.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China. fanghua09@hotmail.com., Wang XF; Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China. wang_xfu@126.com., Wang DZ; Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. vendeezone@126.com., Hu WM; Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. huwm@sysucc.org.cn.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Mar 05; Vol. 14 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2051-5960
DOI:10.1186/s40478-026-02246-6