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Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.

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Title: Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.
Authors: Yao ZG; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Department of Pathology, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China., Li XL; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Wen WJ; Department of Pathology, Liaocheng People's Hospital, Liaocheng, 252000, Shandong, China., Lin XY; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Zhang GH; Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong, China., Sun YP; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Nie YC; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Zheng ZM; Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Xu YQ; Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China., Yang M; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Yu TF; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Dong Y; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Hou YH; Department of Pathology and Center for Molecular Medicine Testing, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.; Department of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Dang LL; Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China., Chu SG; Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China., Li JM; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Ma JW; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Wang Z; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China., Hua F; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, China. fanghua09@hotmail.com.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China. fanghua09@hotmail.com., Wang XF; Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China. wang_xfu@126.com., Wang DZ; Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. vendeezone@126.com., Hu WM; Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. huwm@sysucc.org.cn.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Mar 05; Vol. 14 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.
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  Data: <searchLink fieldCode="AU" term="%22Yao+ZG%22">Yao ZG</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.; Department of Pathology, Cheeloo College of Medicine, Shandong University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Li+XL%22">Li XL</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Wen+WJ%22">Wen WJ</searchLink>; Department of Pathology, Liaocheng People's Hospital, Liaocheng, 252000, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Lin+XY%22">Lin XY</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+GH%22">Zhang GH</searchLink>; Department of Pathology, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, 250014, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Sun+YP%22">Sun YP</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Nie+YC%22">Nie YC</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Zheng+ZM%22">Zheng ZM</searchLink>; Department of Neurosurgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Xu+YQ%22">Xu YQ</searchLink>; Department of Pathology, Xijing Hospital, The Fourth Military Medical University, Xi'an, 710032, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Yu+TF%22">Yu TF</searchLink>; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Dong+Y%22">Dong Y</searchLink>; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Hou+YH%22">Hou YH</searchLink>; Department of Pathology and Center for Molecular Medicine Testing, College of Basic Medicine, Chongqing Medical University, Chongqing, 400016, China.; Department of Pathology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.<br /><searchLink fieldCode="AU" term="%22Dang+LL%22">Dang LL</searchLink>; Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Chu+SG%22">Chu SG</searchLink>; Department of Radiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.<br /><searchLink fieldCode="AU" term="%22Li+JM%22">Li JM</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Ma+JW%22">Ma JW</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Wang+Z%22">Wang Z</searchLink>; Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.<br /><searchLink fieldCode="AU" term="%22Hua+F%22">Hua F</searchLink>; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan, 250012, China. fanghua09@hotmail.com.; Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, 250012, China. fanghua09@hotmail.com.<br /><searchLink fieldCode="AU" term="%22Wang+XF%22">Wang XF</searchLink>; Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian, China. wang_xfu@126.com.<br /><searchLink fieldCode="AU" term="%22Wang+DZ%22">Wang DZ</searchLink>; Department of Pathology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. vendeezone@126.com.<br /><searchLink fieldCode="AU" term="%22Hu+WM%22">Hu WM</searchLink>; Department of Pathology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. huwm@sysucc.org.cn.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 Mar 05; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE
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