Cytosine base editing of LPA in transgenic mice averts large deletions.

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Title: Cytosine base editing of LPA in transgenic mice averts large deletions.
Authors: Chuecos MA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA; Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA., Park SH; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Bhakta MM; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Too-Chiobi U; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Betancourth D; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Cao M; Department of Bioengineering, Rice University, Houston, TX 77030, USA., De Giorgi M; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Walkey CJ; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA., Tiwari A; Center for BioNanoEngineering, Houston Methodist Research Institute, Houston, TX 77030, USA., Godin B; Center for BioNanoEngineering, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Obstetrics and Gynecology, Houston Methodist Hospital, Houston, TX 77030, USA; Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA., Assini JM; Robarts Research Institute, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5B7, Canada., Palmer DJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Ng P; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Boffa MB; Robarts Research Institute, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Biochemistry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5B7, Canada., Koschinsky ML; Robarts Research Institute, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5B7, Canada; Department of Physiology & Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5B7, Canada., Bao G; Department of Bioengineering, Rice University, Houston, TX 77030, USA., Lagor WR; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA; Translational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: lagor@bcm.edu.
Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2026 Jun 03; Vol. 34 (6), pp. 3334-3352. Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1525-0024
DOI:10.1016/j.ymthe.2026.02.049