TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants.
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| Title: | TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants. |
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| Authors: | Gao Z; Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; Key Laboratory for Reproductive Medicine of Guangdong Province; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Liu Q; Division of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of Ministry of Education, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China., Li L; Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; Key Laboratory for Reproductive Medicine of Guangdong Province; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Hu T; Department of Medical Genetics, Key Laboratory of Birth Defects and Related Disease of Women and Children of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China., Lu X; Institute of Women, Children and Reproductive Health, State Key Laboratory of Reproductive Medicine and Offspring Health, Shandong University, Jinan, China., Wu Y; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Qin D; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Wang X; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Gu C; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Li J; Division of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of Ministry of Education, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China., Xu C; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Zhou D; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China., Zhou F; Department of Medical Genetics, Key Laboratory of Birth Defects and Related Disease of Women and Children of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, China., Bai Y; Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; Key Laboratory for Reproductive Medicine of Guangdong Province; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Kang X; Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; Key Laboratory for Reproductive Medicine of Guangdong Province; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China., Liu J; Department of Obstetrics and Gynecology, Center for Reproductive Medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; Key Laboratory for Reproductive Medicine of Guangdong Province; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China. liujqssz@gzhmu.edu.cn., Deng D; Division of Obstetrics, Key Laboratory of Birth Defects and Related Disease of Women and Children of Ministry of Education, State Key Laboratory of Biotherapy, West China Second Hospital, Sichuan University, Chengdu, China. dengd@scu.edu.cn., Li L; The Key Laboratory of Organ Regeneration and Reconstruction, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China. lil@ioz.ac.cn. |
| Source: | Nature communications [Nat Commun] 2026 Mar 05; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 05. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-69744-y |
