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A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice.

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Title: A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice.
Authors: Mayeri Z; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA. zmayeri@buckinstitute.org., Woods G; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Rane A; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Kifle A; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Chamoli M; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Shukla S; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Walton CC; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Andersen JK; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA. jandersen@buckinstitute.org.
Source: GeroScience [Geroscience] 2026 Mar 06. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2509-2723
DOI:10.1007/s11357-026-02139-5