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A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice.

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Title: A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice.
Authors: Mayeri Z; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA. zmayeri@buckinstitute.org., Woods G; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Rane A; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Kifle A; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Chamoli M; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Shukla S; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Walton CC; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA., Andersen JK; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA. jandersen@buckinstitute.org.
Source: GeroScience [Geroscience] 2026 Mar 06. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice.
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  Data: <searchLink fieldCode="AU" term="%22Mayeri+Z%22">Mayeri Z</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA. zmayeri@buckinstitute.org.<br /><searchLink fieldCode="AU" term="%22Woods+G%22">Woods G</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Rane+A%22">Rane A</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Kifle+A%22">Kifle A</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Chamoli+M%22">Chamoli M</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Shukla+S%22">Shukla S</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Walton+CC%22">Walton CC</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA.<br /><searchLink fieldCode="AU" term="%22Andersen+JK%22">Andersen JK</searchLink>; Buck Institute for Research On Aging, 8001 Redwood Boulevard, Novato, CA, 94945, USA. jandersen@buckinstitute.org.
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  Data: <searchLink fieldCode="JN" term="%22101686284%22">GeroScience</searchLink> [Geroscience] 2026 Mar 06. <i>Date of Electronic Publication: </i>2026 Mar 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+International+Publishing%22">Springer International Publishing </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101686284 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2509-2723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225092723%22">25092723 </searchLink><i>NLM ISO Abbreviation: </i>Geroscience <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1007/s11357-026-02139-5
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      – Code: eng
        Text: English
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      – TitleFull: A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice.
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            NameFull: Mayeri Z
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            NameFull: Woods G
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            – D: 06
              M: 03
              Text: 2026 Mar 06
              Type: published
              Y: 2026
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              Value: 2509-2723
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