Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1-PD-L1 axis: a multi-omics and clinical validation study.
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| Title: | Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1-PD-L1 axis: a multi-omics and clinical validation study. |
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| Authors: | Qin H; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China., Qi T; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China., Yao N; Department of Pathology, Bengbu Medical University, Bengbu, Anhui, China., Sheng W; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China., Deng J; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China., Qian J; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China., Wang D; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China., Zeng H; Department of Orthopedics, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China., Weng J; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. jweng@pku.edu.cn., Yang J; Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. junyang@pkuszh.com., Yu F; Department of Spine Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China. yufei89@pku.edu.cn. |
| Source: | NPJ precision oncology [NPJ Precis Oncol] 2026 Mar 06; Vol. 10 (1). Date of Electronic Publication: 2026 Mar 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41792370 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1-PD-L1 axis: a multi-omics and clinical validation study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Qin+H%22">Qin H</searchLink>; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Qi+T%22">Qi T</searchLink>; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Yao+N%22">Yao N</searchLink>; Department of Pathology, Bengbu Medical University, Bengbu, Anhui, China.<br /><searchLink fieldCode="AU" term="%22Sheng+W%22">Sheng W</searchLink>; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Deng+J%22">Deng J</searchLink>; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Qian+J%22">Qian J</searchLink>; Department of Orthopedics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China.; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+D%22">Wang D</searchLink>; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zeng+H%22">Zeng H</searchLink>; Department of Orthopedics, Medical Innovation Technology Transformation Center of Shenzhen Second People's Hospital, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Weng+J%22">Weng J</searchLink>; Department of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. jweng@pku.edu.cn.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Department of Radiology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China. junyang@pkuszh.com.<br /><searchLink fieldCode="AU" term="%22Yu+F%22">Yu F</searchLink>; Department of Spine Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, China. yufei89@pku.edu.cn. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101708166%22">NPJ precision oncology</searchLink> [NPJ Precis Oncol] 2026 Mar 06; Vol. 10 (1). <i>Date of Electronic Publication: </i>2026 Mar 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101708166 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2397-768X (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%222397768X%22">2397768X </searchLink><i>NLM ISO Abbreviation: </i>NPJ Precis Oncol <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41792370 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41698-026-01298-0 Languages: – Code: eng Text: English Titles: – TitleFull: Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1-PD-L1 axis: a multi-omics and clinical validation study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Qin H – PersonEntity: Name: NameFull: Qi T – PersonEntity: Name: NameFull: Yao N – PersonEntity: Name: NameFull: Sheng W – PersonEntity: Name: NameFull: Deng J – PersonEntity: Name: NameFull: Qian J – PersonEntity: Name: NameFull: Wang D – PersonEntity: Name: NameFull: Zeng H – PersonEntity: Name: NameFull: Weng J – PersonEntity: Name: NameFull: Yang J – PersonEntity: Name: NameFull: Yu F IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 03 Text: 2026 Mar 06 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 2397-768X Numbering: – Type: volume Value: 10 – Type: issue Value: 1 Titles: – TitleFull: NPJ precision oncology Type: main |
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