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Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma.

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Title: Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma.
Authors: Richardson SA; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Safrastyan A; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Karimpour M; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Gulati G; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Harker PJB; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Redfern A; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Pearce SP; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Makeev VJ; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Brennan B; Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK., Lee ATJ; The Christie NHS Foundation Trust, Manchester, M20 4BX, UK., Clipson A; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Hill SM; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Dive C; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., Rothwell DG; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK., McCabe MG; The Christie NHS Foundation Trust, Manchester, M20 4BX, UK. martin.mccabe@manchester.ac.uk.; Division of Cancer Sciences, University of Manchester, Manchester, UK. martin.mccabe@manchester.ac.uk., Mouliere F; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK. florent.mouliere@cruk.manchester.ac.uk.
Source: EMBO molecular medicine [EMBO Mol Med] 2026 Apr; Vol. 18 (4), pp. 1342-1357. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Cell-free DNA methylome and fragmentome analysis for relapse monitoring of Ewing sarcoma.
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  Data: <searchLink fieldCode="AU" term="%22Richardson+SA%22">Richardson SA</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Safrastyan+A%22">Safrastyan A</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Karimpour+M%22">Karimpour M</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Gulati+G%22">Gulati G</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Harker+PJB%22">Harker PJB</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Redfern+A%22">Redfern A</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Pearce+SP%22">Pearce SP</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Makeev+VJ%22">Makeev VJ</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Brennan+B%22">Brennan B</searchLink>; Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK.<br /><searchLink fieldCode="AU" term="%22Lee+ATJ%22">Lee ATJ</searchLink>; The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Clipson+A%22">Clipson A</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Hill+SM%22">Hill SM</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Dive+C%22">Dive C</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22Rothwell+DG%22">Rothwell DG</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK.<br /><searchLink fieldCode="AU" term="%22McCabe+MG%22">McCabe MG</searchLink>; The Christie NHS Foundation Trust, Manchester, M20 4BX, UK. martin.mccabe@manchester.ac.uk.; Division of Cancer Sciences, University of Manchester, Manchester, UK. martin.mccabe@manchester.ac.uk.<br /><searchLink fieldCode="AU" term="%22Mouliere+F%22">Mouliere F</searchLink>; Cancer Research UK National Biomarker Centre, University of Manchester, Manchester, M20 4BX, UK. florent.mouliere@cruk.manchester.ac.uk.
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              Text: 2026 Apr
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