Is high insulin protective or detrimental? Mathematical modeling reveals the base of the iceberg.

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Title: Is high insulin protective or detrimental? Mathematical modeling reveals the base of the iceberg.
Authors: Yang B; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States., Ha J; Department of Mathematics, Howard University, Washington, District of Columbia, United States., Sherman AS; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2026 May 01; Vol. 330 (5), pp. E627-E640. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1522-1555
DOI:10.1152/ajpendo.00414.2025