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Is high insulin protective or detrimental? Mathematical modeling reveals the base of the iceberg.

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Title: Is high insulin protective or detrimental? Mathematical modeling reveals the base of the iceberg.
Authors: Yang B; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States., Ha J; Department of Mathematics, Howard University, Washington, District of Columbia, United States., Sherman AS; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.
Source: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2026 May 01; Vol. 330 (5), pp. E627-E640. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.<br /><searchLink fieldCode="AU" term="%22Ha+J%22">Ha J</searchLink>; Department of Mathematics, Howard University, Washington, District of Columbia, United States.<br /><searchLink fieldCode="AU" term="%22Sherman+AS%22">Sherman AS</searchLink>; Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States.
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  Data: <searchLink fieldCode="JN" term="%22100901226%22">American journal of physiology. Endocrinology and metabolism</searchLink> [Am J Physiol Endocrinol Metab] 2026 May 01; Vol. 330 (5), pp. E627-E640. <i>Date of Electronic Publication: </i>2026 Mar 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Physiological+Society%22">American Physiological Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>100901226 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1522-1555 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201931849%22">01931849 </searchLink><i>NLM ISO Abbreviation: </i>Am J Physiol Endocrinol Metab <i>Subsets: </i>MEDLINE
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        Value: 10.1152/ajpendo.00414.2025
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      – Code: eng
        Text: English
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      – TitleFull: Is high insulin protective or detrimental? Mathematical modeling reveals the base of the iceberg.
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              Text: 2026 May 01
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              Y: 2026
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