Epilepsy-associated FOXJ3 variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination.
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| Title: | Epilepsy-associated FOXJ3 variants link a transcriptional program of the PTEN-mTOR pathway to neuronal specification and cortical lamination. |
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| Authors: | Cheng HY; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells and GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, Liège, Belgium., Liu C; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Nien CW; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Huang HC; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Zhao HJ; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Nian FS; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Laboratory of Molecular Regulation of Neurogenesis, GIGA-Stem Cells and GIGA-Neurosciences, Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, Liège, Belgium., Chen C; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University College of Medicine Taipei, Taipei, Taiwan.; Division of Epilepsy, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan., Custodio HM; Research Department of Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, and Chalfont Centre for Epilepsy, Buckinghamshire, London, UK., Sisodiya SM; Research Department of Epilepsy, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, and Chalfont Centre for Epilepsy, Buckinghamshire, London, UK., Lu C; School of Medicine, National Yang Ming Chiao Tung University College of Medicine Taipei, Taipei, Taiwan., Chen HH; School of Medicine, National Yang Ming Chiao Tung University College of Medicine Taipei, Taipei, Taiwan.; Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan., Hsu CS; Genomics Center for Clinical and Biotechnological Applications, Cancer and Immunology Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Pi WC; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chu CC; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan., Hsu JS; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan., Chen PL; Graduate Institute of Medical Genomics and Proteomics, College of Medicine, National Taiwan University, Taipei, Taiwan.; Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan., Chang FP; Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan., Tung CY; Genomics Center for Clinical and Biotechnological Applications, Cancer and Immunology Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chou SJ; Neuroscience Program of Academia Sinica (NPAS), Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan., Alavi S; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Houlden H; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK., Chen WY; Institute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan., Liu YT; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. ytliu2@vghtpe.gov.tw.; School of Medicine, National Yang Ming Chiao Tung University College of Medicine Taipei, Taipei, Taiwan. ytliu2@vghtpe.gov.tw.; Division of Epilepsy, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. ytliu2@vghtpe.gov.tw.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. ytliu2@vghtpe.gov.tw., Hou PS; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. pshou@nycu.edu.tw.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. pshou@nycu.edu.tw.; Institute of Anatomy and Cell Biology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. pshou@nycu.edu.tw., Tsai JW; Institute of Brain Science, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. tsaijw@nycu.edu.tw.; Brain Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. tsaijw@nycu.edu.tw.; Advanced Therapeutics Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan. tsaijw@nycu.edu.tw.; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. tsaijw@nycu.edu.tw. |
| Source: | Nature communications [Nat Commun] 2026 Mar 09; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2041-1723 |
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| DOI: | 10.1038/s41467-026-69241-2 |
