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Methionine restriction provides sex-specific protection against high-fat diet-induced adiposity, peripheral insulin resistance, and neuroinflammation in FGF21-dependent and independent manners in mice.

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Title: Methionine restriction provides sex-specific protection against high-fat diet-induced adiposity, peripheral insulin resistance, and neuroinflammation in FGF21-dependent and independent manners in mice.
Authors: Lail H; Department of Nutrition, Georgia State University, Atlanta, Georgia, United States of America.; Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America., Lawrence R; Department of Neuroscience, Georgia State University, Atlanta, Georgia, United States of America., Pinheiro F; Department of Biomedicine, University of Porto Faculty of Medicine, Alameda Prof. Hernâni Monteiro, Porto, Portugal.; Center for Health Technology and Services Research, University of Porto Faculty of Medicine, Alameda Prof. Hernâni Monteiro, Porto, Portugal., Price E; Department of Nutrition, Georgia State University, Atlanta, Georgia, United States of America.; Clinical Psychology, Immaculata University, Immaculata, United States of America., Wanders D; Department of Nutrition, Georgia State University, Atlanta, Georgia, United States of America.; Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America.
Source: PloS one [PLoS One] 2026 Mar 10; Vol. 21 (3), pp. e0343503. Date of Electronic Publication: 2026 Mar 10 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0343503