GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization.
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| Title: | GNPAT promotes immunosuppression in hepatocellular carcinoma by activating the plasmalogen-PPARγ pathway to drive M2 macrophage polarization. |
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| Authors: | Hu M; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China.; Department of Complex Preparation, Shijiazhuang No. 4 Pharmaceutical, Shijiazhuang, Hebei, China., Zhang N; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China.; College of Integrative Chinese and Western Medicine, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China., Wang YQ; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China.; Department of Clinical Laboratory, Hebei Province Hospital of Chinese Medicine, Shijiazhuang, Hebei, China., Wang XM; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China.; Department of Clinical Laboratory, The First Hospital of Tsinghua University, Beijing, China., Shi Y; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China., Yao M; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China., Hou LG; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China., Jiang LL; Ministry of Education Key Laboratory of Neural and Vascular Biologys, Department of Biochemistry and Molecular Biology, Hebei Medical University, Shijiazhuang, Hebei, China. |
| Source: | Frontiers in immunology [Front Immunol] 2026 Feb 24; Vol. 17, pp. 1765930. Date of Electronic Publication: 2026 Feb 24 (Print Publication: 2026). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2026.1765930 |
