CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder.
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| Title: | CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder. |
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| Authors: | Chi L; Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Institute of Stomatological Research, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Tu H; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore., Li Z; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore., Qiu L; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Zhang ZW; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Chia SY; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Tan JY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Ho IAW; Molecular Neurotherapeutics Laboratory, National Neuroscience Institute, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Loh YH; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore., Tan EK; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore, Singapore., Teng W; Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Institute of Stomatological Research, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China., Pei Z; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-Sen University, Guangzhou, China., Wszolek ZK; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA., Ng ASL; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Zeng L; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore. Li_Zeng@nni.com.sg.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore. Li_Zeng@nni.com.sg.; Centre for Molecular Neuropathology, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Li_Zeng@nni.com.sg. |
| Source: | Cell death discovery [Cell Death Discov] 2026 Mar 12; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2058-7716 |
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| DOI: | 10.1038/s41420-026-02995-2 |
