View in EDS HTML Full Text PDF Full Text

CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder.

Saved in:
Bibliographic Details
Title: CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder.
Authors: Chi L; Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Institute of Stomatological Research, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Tu H; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore., Li Z; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore., Qiu L; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Zhang ZW; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Chia SY; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore., Tan JY; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Ho IAW; Molecular Neurotherapeutics Laboratory, National Neuroscience Institute, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Loh YH; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore., Tan EK; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore, Singapore., Teng W; Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Institute of Stomatological Research, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China., Pei Z; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-Sen University, Guangzhou, China., Wszolek ZK; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA., Ng ASL; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore, Singapore., Zeng L; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore. Li_Zeng@nni.com.sg.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore. Li_Zeng@nni.com.sg.; Centre for Molecular Neuropathology, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Li_Zeng@nni.com.sg.
Source: Cell death discovery [Cell Death Discov] 2026 Mar 12; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 12.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 41820324
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Chi+L%22">Chi L</searchLink>; Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Institute of Stomatological Research, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tu+H%22">Tu H</searchLink>; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Qiu+L%22">Qiu L</searchLink>; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zhang+ZW%22">Zhang ZW</searchLink>; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Chia+SY%22">Chia SY</searchLink>; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+JY%22">Tan JY</searchLink>; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Ho+IAW%22">Ho IAW</searchLink>; Molecular Neurotherapeutics Laboratory, National Neuroscience Institute, Singapore, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Loh+YH%22">Loh YH</searchLink>; Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Tan+EK%22">Tan EK</searchLink>; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.; Research Department, National Neuroscience Institute, Singapore General Hospital (SGH) Campus, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Teng+W%22">Teng W</searchLink>; Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Institute of Stomatological Research, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Pei+Z%22">Pei Z</searchLink>; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, Department of Neurology, The First Affiliated Hospital; National Key Clinical Department and Key Discipline of Neurology, Sun Yat-Sen University, Guangzhou, China.<br /><searchLink fieldCode="AU" term="%22Wszolek+ZK%22">Wszolek ZK</searchLink>; Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, USA.<br /><searchLink fieldCode="AU" term="%22Ng+ASL%22">Ng ASL</searchLink>; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore.; Department of Neurology, National Neuroscience Institute, Singapore, Singapore.<br /><searchLink fieldCode="AU" term="%22Zeng+L%22">Zeng L</searchLink>; Neural Stem Cell Research Lab, Research Department, National Neuroscience Institute, Singapore, Singapore. Li_Zeng@nni.com.sg.; Neuroscience & Behavioral Disorders Program, DUKE-NUS Graduate Medical School, Singapore, Singapore. Li_Zeng@nni.com.sg.; Centre for Molecular Neuropathology, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Li_Zeng@nni.com.sg.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Mar 12; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Mar 12.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41820324
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/s41420-026-02995-2
    Languages:
      – Code: eng
        Text: English
    Titles:
      – TitleFull: CSF1R T567M mutation induces microglial dysfunction and synaptic impairment in patient iPSC-derived cerebral organoids of CSF1R-related disorder.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Chi L
      – PersonEntity:
          Name:
            NameFull: Tu H
      – PersonEntity:
          Name:
            NameFull: Li Z
      – PersonEntity:
          Name:
            NameFull: Qiu L
      – PersonEntity:
          Name:
            NameFull: Zhang ZW
      – PersonEntity:
          Name:
            NameFull: Chia SY
      – PersonEntity:
          Name:
            NameFull: Tan JY
      – PersonEntity:
          Name:
            NameFull: Ho IAW
      – PersonEntity:
          Name:
            NameFull: Loh YH
      – PersonEntity:
          Name:
            NameFull: Tan EK
      – PersonEntity:
          Name:
            NameFull: Teng W
      – PersonEntity:
          Name:
            NameFull: Pei Z
      – PersonEntity:
          Name:
            NameFull: Wszolek ZK
      – PersonEntity:
          Name:
            NameFull: Ng ASL
      – PersonEntity:
          Name:
            NameFull: Zeng L
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 12
              M: 03
              Text: 2026 Mar 12
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 2058-7716
          Numbering:
            – Type: volume
              Value: 12
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Cell death discovery
              Type: main
ResultId 1