PARK19 truncation mutant Dnajc6 causes lysosomal deficiency-induced upregulation of pathologic α-synuclein and neurodegeneration of substantia nigra dopaminergic cells in PARK19 knockin mice.
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| Title: | PARK19 truncation mutant Dnajc6 causes lysosomal deficiency-induced upregulation of pathologic α-synuclein and neurodegeneration of substantia nigra dopaminergic cells in PARK19 knockin mice. |
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| Authors: | Wang HL; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Chen YL; Department of Nursing, Chang Gung University of Science and Technology, Taoyuan, Taiwan., Chiu TJ; Graduate Institute of Biomedical Sciences, Chang Gung University College of Medicine, Taoyuan, Taiwan., Chiu CC; Healthy Aging Research Center, Chang Gung University College of Medicine, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Department of Medical Biotechnology and Laboratory Science, Chang Gung University College of Medicine, Taoyuan, Taiwan., Weng YH; Division of Movement Disorders, Department of Neurology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Neuroscience Research Center, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Liu SY; Department of Physiology and Pharmacology, Chang Gung University College of Medicine, Taoyuan, Taiwan., Li AH; Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Yeh TH; Department of Neurology, Taipei Medical University Hospital, Taipei, Taiwan. do2739@tmu.edu.tw.; School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. do2739@tmu.edu.tw.; Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. do2739@tmu.edu.tw. |
| Source: | NPJ Parkinson's disease [NPJ Parkinsons Dis] 2026 Mar 12; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 12. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101675390 Publication Model: Electronic Cited Medium: Print ISSN: 2373-8057 (Print) Linking ISSN: 23738057 NLM ISO Abbreviation: NPJ Parkinsons Dis Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 2373-8057 |
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| DOI: | 10.1038/s41531-026-01317-8 |
