Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues.

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Title: Systematic evaluation of single-cell multimodal data integration enhances cell type resolution and discovery of clinically relevant states in complex tissues.
Authors: Acera-Mateos M; Josep Carreras Leukemia Research Institute, Barcelona, Spain.; University of Barcelona (UB), Barcelona, Spain., Adiconis X; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Li JK; Josep Carreras Leukemia Research Institute, Barcelona, Spain., Marchese D; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain., Caratù G; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain., Hon CC; Laboratory for Regulatory Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan., Tiwari P; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan., Kojima M; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan., Vieth B; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, Planegg, 82152, Germany., Murphy MA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Present address: Osmo, New York, NY, 10016, USA., Simmons SK; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA., Lefevre T; Department of Human Genetics, University of Leuven, KU Leuven, Louvain, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), University of Leuven, KU Leuven, Louvain, Belgium., Claes I; Department of Human Genetics, University of Leuven, KU Leuven, Louvain, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), University of Leuven, KU Leuven, Louvain, Belgium., O'Connor CL; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Menon R; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Otto EA; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Ando Y; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan., Vandereyken K; Department of Human Genetics, University of Leuven, KU Leuven, Louvain, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), University of Leuven, KU Leuven, Louvain, Belgium., Kretzler M; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Bitzer M; Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA., Fraenkel E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Voet T; Department of Human Genetics, University of Leuven, KU Leuven, Louvain, Belgium.; KU Leuven Institute for Single Cell Omics (LISCO), University of Leuven, KU Leuven, Louvain, Belgium., Enard W; Anthropology and Human Genomics, Faculty of Biology, Ludwig-Maximilians Universität München, Planegg, 82152, Germany., Carninci P; Laboratory for Transcriptome Technology, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.; Human Technopole, Milan, Italy., Heyn H; University of Barcelona (UB), Barcelona, Spain.; Centro Nacional de Análisis Genómico (CNAG), Barcelona, Spain.; ICREA, Barcelona, Spain., Levin JZ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. jlevin@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. jlevin@broadinstitute.org., Mereu E; Josep Carreras Leukemia Research Institute, Barcelona, Spain. emereu@carrerasresearch.org.
Source: Genome biology [Genome Biol] 2026 Mar 13; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1474-760X
DOI:10.1186/s13059-026-04002-4