Discovering patterns in the pathologic significance of non-missense deleterious variants in RELA.

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Title: Discovering patterns in the pathologic significance of non-missense deleterious variants in RELA.
Authors: Hayakawa H; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan., Tsumura M; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan., Utsumi T; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan., Nihira H; Department of Immunology, Kurume University School of Medicine, Kurume, Japan., Lei WT; Center for the Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Division of Immunology, Rheumatology, and Allergy, Department of Pediatrics, Hsinchu Municipal MacKay Children's Hospital, Hsinchu, Taiwan; Department of Medicine, MacKay Medical University, New Taipei, Taiwan., Ogino R; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Bucciol G; Laboratory for Inborn Errors of Immunity, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Leuven, Belgium., Nakano T; Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Japan., Amo K; Department of Pediatric Emergency and Infectious Diseases, Osaka City General Hospital, Osaka, Japan., Moriya K; Department of Pediatrics, National Defense Medical College, Saitama, Japan., Hayakawa S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan., Mizoguchi Y; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan., Karakawa S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan., Lin YN; Center for the Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan., Shih HP; Center for the Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan., Lo CC; Center for the Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan., Janssenswillen S; Center for Molecular Genetics, University Hospitals Leuven, Leuven, Belgium., Van Loo S; Center for Molecular Genetics, University Hospitals Leuven, Leuven, Belgium., Mekahli D; PKD Research Group, Laboratory of Ion Channel Research, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium., Bogunovic D; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan; Center for Genetic Errors of Immunity, Department of Pediatrics, Columbia University Medical Center, New York, NY., Boisson-Dupuis S; St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY; Laboratory of Human Genetics of Infectious Diseases, Inserm U1163, Paris, France; Paris Cité University, Imagine Institute, Paris, France., Izawa K; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan., Ku CL; Center for the Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Institute of Immunology and Translational Medicine, Chang Gung University, Taoyuan, Taiwan; Laboratory of Human Immunology and Infectious Diseases, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan, Taiwan; Division of Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Yasumi T; Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan; Japan Environment and Children's Study (JECS) Kyoto Regional Center, Kyoto University Graduate School of Medicine, Kyoto, Japan., Asano T; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan; Department of Genetics and Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan., Meyts I; Laboratory for Inborn Errors of Immunity, Department of Pediatrics, University Hospitals Leuven, KU Leuven, Leuven, Belgium., Okada S; Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan. Electronic address: sokada@hiroshima-u.ac.jp.
Source: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2026 Mar 13. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1097-6825
DOI:10.1016/j.jaci.2026.01.020