HIV-1-encoded circular RNA enhances viral transcription through Tat binding.

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Title: HIV-1-encoded circular RNA enhances viral transcription through Tat binding.
Authors: Obi P; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yan L; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Dujsikova A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yeh YJ; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Li I; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Mueller NL; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Back H; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Yi B; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Liu N; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Mbadugha F; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Yu H; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Brown C; Department of Molecular Biochemistry and Biophysics, Yale University School of Medicine, New Haven, CT, USA., St Denis K; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Landry ML; Department of Medicine (Infectious Diseases), Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA., Sumigray K; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA., Emu B; Department of Medicine (Infectious Diseases), Yale University School of Medicine, New Haven, CT, USA., Ho YC; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Chen YG; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. ye.grace.chen@yale.edu.; Department of Genetics, Yale University School of Medicine, New Haven, CT, USA. ye.grace.chen@yale.edu.
Source: Nature microbiology [Nat Microbiol] 2026 Apr; Vol. 11 (4), pp. 1008-1021. Date of Electronic Publication: 2026 Mar 13.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:2058-5276
DOI:10.1038/s41564-026-02271-0