Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.

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Title: Alexander disease mutations differentially sensitize glial fibrillary acidic protein (GFAP) to posttranslational modifications and network disruption by oxidants.
Authors: Goya-Iglesias N; Department of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain., Hägglund P; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark., Martínez-Cenalmor P; Department of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain., Nybo T; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark., Lorentzen LG; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark., Pajares MA; Department of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain., Davies MJ; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, 2200, Denmark. Electronic address: davies@sund.ku.dk., Pérez-Sala D; Department of Molecular and Cellular and Biosciences, Centro de Investigaciones Biológicas Margarita Salas, C.S.I.C., Madrid, 28040, Spain. Electronic address: dperezsala@cib.csic.es.
Source: Redox biology [Redox Biol] 2026 May; Vol. 92, pp. 104103. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2213-2317
DOI:10.1016/j.redox.2026.104103