Single-cell RNA-seq of in vitro-cultured medullary thymic epithelial cells reveals a preserved differentiation trajectory under Aire deficiency.

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Title: Single-cell RNA-seq of in vitro-cultured medullary thymic epithelial cells reveals a preserved differentiation trajectory under Aire deficiency.
Authors: Mascarenhas RS; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil., Duarte MJ; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil., Tanaka PP; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil., Oliveira EH; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil., Monteiro CJ; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil., Vieira-Machado MC; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil., Donadi EA; Department of Medicine, Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil., Passos GA; Molecular Immunogenetics Group, Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Via Bandeirantes, 3900, Ribeirão Preto Campus, SP 14040-900, Brazil.; Laboratory of Genetics and Molecular Biology, Department of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Via do Café s/n, Ribeirão Preto Campus, SP 14040-904, Brazil.
Source: Journal of leukocyte biology [J Leukoc Biol] 2026 Mar 03; Vol. 118 (3).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1938-3673
DOI:10.1093/jleuko/qiag038