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ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition.

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Title: ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition.
Authors: Zheng Z; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Pettus JH; Division of Endocrinology, Altman Clinical and Translational Research Institute (ACTRI), University of California, San Diego, 9452 Medical Center Drive L1W-515, La Jolla, CA, 92037, USA., Warner A; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Jones B; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Pugsley M; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Stege J; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Hirakawa B; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Jaiman M; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Tolentino J; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Lee TL; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Kieffer TJ; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA; Life Sciences Institute, Department of Cellular and Physiological Sciences, Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, V6T1Z3, Canada. Electronic address: tim.kieffer@aardvarktherapeutics.com.
Source: Molecular metabolism [Mol Metab] 2026 Apr; Vol. 106, pp. 102340. Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2212-8778
DOI:10.1016/j.molmet.2026.102340