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ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition.

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Title: ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition.
Authors: Zheng Z; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Pettus JH; Division of Endocrinology, Altman Clinical and Translational Research Institute (ACTRI), University of California, San Diego, 9452 Medical Center Drive L1W-515, La Jolla, CA, 92037, USA., Warner A; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Jones B; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Pugsley M; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Stege J; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Hirakawa B; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Jaiman M; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Tolentino J; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Lee TL; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA., Kieffer TJ; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA; Life Sciences Institute, Department of Cellular and Physiological Sciences, Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, V6T1Z3, Canada. Electronic address: tim.kieffer@aardvarktherapeutics.com.
Source: Molecular metabolism [Mol Metab] 2026 Apr; Vol. 106, pp. 102340. Date of Electronic Publication: 2026 Mar 14.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: ARD-101, a gut-restricted TAS2R agonist, reduces hunger in adults and promotes weight loss in DIO mice with DPP-4 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Zheng+Z%22">Zheng Z</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Pettus+JH%22">Pettus JH</searchLink>; Division of Endocrinology, Altman Clinical and Translational Research Institute (ACTRI), University of California, San Diego, 9452 Medical Center Drive L1W-515, La Jolla, CA, 92037, USA.<br /><searchLink fieldCode="AU" term="%22Warner+A%22">Warner A</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Jones+B%22">Jones B</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Pugsley+M%22">Pugsley M</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Stege+J%22">Stege J</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Hirakawa+B%22">Hirakawa B</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Jaiman+M%22">Jaiman M</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Tolentino+J%22">Tolentino J</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Lee+TL%22">Lee TL</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA.<br /><searchLink fieldCode="AU" term="%22Kieffer+TJ%22">Kieffer TJ</searchLink>; Aardvark Therapeutics, 4370 La Jolla Village Drive, Suite 1050, San Diego, CA, 92122, USA; Life Sciences Institute, Department of Cellular and Physiological Sciences, Department of Surgery, School of Biomedical Engineering, University of British Columbia, Vancouver, BC, V6T1Z3, Canada. Electronic address: tim.kieffer@aardvarktherapeutics.com.
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  Data: <searchLink fieldCode="JN" term="%22101605730%22">Molecular metabolism</searchLink> [Mol Metab] 2026 Apr; Vol. 106, pp. 102340. <i>Date of Electronic Publication: </i>2026 Mar 14.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+GmbH%22">Elsevier GmbH </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>101605730 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2212-8778 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2222128778%22">22128778 </searchLink><i>NLM ISO Abbreviation: </i>Mol Metab <i>Subsets: </i>MEDLINE
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              Text: 2026 Apr
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