Spatiotemporal immune gradients in gout: immune response-driven activation of the NLRP3-IL-1β axis and its transition to trained immunity.

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Title: Spatiotemporal immune gradients in gout: immune response-driven activation of the NLRP3-IL-1β axis and its transition to trained immunity.
Authors: Wang K; Orthopedics Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, China., Li J; Department of Orthopedics, Huaihua City Hospital of Traditional Chinese Medicine, Huaihua, China., Li J; Graduate School, Hunan University of Chinese Medicine, Changsha, China., Zeng F; Department of Orthopedics, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China., Li S; Department of Orthopedics, Huaihua City Hospital of Traditional Chinese Medicine, Huaihua, China., Chen P; Orthopedics Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, China., Xiong H; Orthopedics Department, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 27; Vol. 17, pp. 1776479. Date of Electronic Publication: 2026 Feb 27 (Print Publication: 2026).
Publication Type: Journal Article; Review
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1664-3224
DOI:10.3389/fimmu.2026.1776479