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Weight Regain Reverses Caloric Restriction-Induced Benefits on the Insulin-IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial.

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Title: Weight Regain Reverses Caloric Restriction-Induced Benefits on the Insulin-IGF-1 Nutrient-Sensing Pathway: Post Hoc Analysis From the CALERIE-2 Randomized Controlled Trial.
Authors: Warmbrunn MV; Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Department of Internal and Vascular Medicine, Amsterdam University Medical Centers, Amsterdam, the Netherlands., Yang L; Department of Cancer Epidemiology and Prevention Research, Cancer Care Alberta, Alberta Health Services, Calgary, Alberta, Canada.; Departments of Oncology and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada., Kishore Biswas R; Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Sydney Local Health District Clinical Research Centre, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia., Ryan CP; Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY., Harper A; Departments of Oncology and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada., Belsky DW; Robert N. Butler Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY., Fiorito G; Clinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.; MRC-PHE Centre for Environment and Health, Imperial College London, London, U.K., Fontana L; Charles Perkins Center, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.; Department of Endocrinology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Source: Diabetes care [Diabetes Care] 2026 May 01; Vol. 49 (5), pp. 783-791.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: American Diabetes Association Country of Publication: United States NLM ID: 7805975 Publication Model: Print Cited Medium: Internet ISSN: 1935-5548 (Electronic) Linking ISSN: 01495992 NLM ISO Abbreviation: Diabetes Care Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Diabetes+Association%22">American Diabetes Association </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>7805975 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1935-5548 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2201495992%22">01495992 </searchLink><i>NLM ISO Abbreviation: </i>Diabetes Care <i>Subsets: </i>MEDLINE
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        Value: 10.2337/dc25-1911
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              Text: 2026 May 01
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