Berberine Ameliorates Angiotensin II-Induced Endothelial Dysfunction by Blocking AT1R, Inhibiting PDE4b and Activating AKT/eNOS Pathway.

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Title: Berberine Ameliorates Angiotensin II-Induced Endothelial Dysfunction by Blocking AT1R, Inhibiting PDE4b and Activating AKT/eNOS Pathway.
Authors: Zhang TY; Department of Cardiovascular Medicine, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Zhao BN; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Wu HW; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Zhang YY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China., Li J; Department of Cardiovascular Medicine, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Liu QM; Department of Cardiovascular Medicine, the Second Xiangya Hospital of Central South University, Changsha, 410011, China., Liu LM; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China. liulm@bjmu.edu.cn., Kang JH; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Source: Chinese journal of integrative medicine [Chin J Integr Med] 2026 Jun; Vol. 32 (6), pp. 536-544. Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Chinese Journal of Integrated Traditional and Western Medicine Press Country of Publication: China NLM ID: 101181180 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1993-0402 (Electronic) Linking ISSN: 16720415 NLM ISO Abbreviation: Chin J Integr Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1993-0402
DOI:10.1007/s11655-026-4034-y