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A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms.

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Title: A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms.
Authors: Huang X; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China., Li Y; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.; Institute for Vaccine Research at Animal Biosafety Level 3 Laboratory, Wuhan University School of Medicine, Wuhan, China., Deng J; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China., Tan X; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China., Yang S; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China., Liu J; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China., Wu Z; GemPharmatech Co. Ltd., Nanjing, China., Shi P; GemPharmatech Chengdu Co. Ltd., Chengdu, China., Zhou L; Institute for Vaccine Research at Animal Biosafety Level 3 Laboratory, Wuhan University School of Medicine, Wuhan, China. zhouli_jerry@whu.edu.cn., Chen Y; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China. chenyu@whu.edu.cn.
Source: Signal transduction and targeted therapy [Signal Transduct Target Ther] 2026 Mar 16; Vol. 11 (1). Date of Electronic Publication: 2026 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101676423 Publication Model: Electronic Cited Medium: Internet ISSN: 2059-3635 (Electronic) Linking ISSN: 20593635 NLM ISO Abbreviation: Signal Transduct Target Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A biosafe mouse model for SARS-CoV-2 infection that more realistically simulates COVID-19 symptoms.
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  Data: <searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.; Institute for Vaccine Research at Animal Biosafety Level 3 Laboratory, Wuhan University School of Medicine, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Deng+J%22">Deng J</searchLink>; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Tan+X%22">Tan X</searchLink>; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Yang+S%22">Yang S</searchLink>; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.<br /><searchLink fieldCode="AU" term="%22Wu+Z%22">Wu Z</searchLink>; GemPharmatech Co. Ltd., Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Shi+P%22">Shi P</searchLink>; GemPharmatech Chengdu Co. Ltd., Chengdu, China.<br /><searchLink fieldCode="AU" term="%22Zhou+L%22">Zhou L</searchLink>; Institute for Vaccine Research at Animal Biosafety Level 3 Laboratory, Wuhan University School of Medicine, Wuhan, China. zhouli_jerry@whu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; State Key Laboratory of Virology and Biosafety, RNA Institute, College of Life Sciences and Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China. chenyu@whu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101676423%22">Signal transduction and targeted therapy</searchLink> [Signal Transduct Target Ther] 2026 Mar 16; Vol. 11 (1). <i>Date of Electronic Publication: </i>2026 Mar 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101676423 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2059-3635 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220593635%22">20593635 </searchLink><i>NLM ISO Abbreviation: </i>Signal Transduct Target Ther <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41839853
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        Value: 10.1038/s41392-026-02640-5
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        Text: English
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              Text: 2026 Mar 16
              Type: published
              Y: 2026
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