Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model.
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| Title: | Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model. |
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| Authors: | Chen JH; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Chang CW; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Chen YY; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Yang CH; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan., Yang WB; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.; Research Center for Neuroscience, Taipei Medical University, Taipei, Taiwan., Hsieh YC; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan., Liang YW; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Li SJ; Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan., Hu CJ; Department of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei, Taiwan.; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.; Ph.D. Program in Medical Neuroscience, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan. |
| Source: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2026 Mar; Vol. 22 (3), pp. e71290. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1552-5279 |
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| DOI: | 10.1002/alz.71290 |
