Dimethyl Fumarate Reverses β-Adrenoceptor-Mediated Myocardial Fibrosis in Mice by Inhibiting Yes-Associated Protein-Regulated Expression of Intermediate-Conductance Ca2+-Activated K+ Channel in Fibroblasts.

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Title: Dimethyl Fumarate Reverses β-Adrenoceptor-Mediated Myocardial Fibrosis in Mice by Inhibiting Yes-Associated Protein-Regulated Expression of Intermediate-Conductance Ca2+-Activated K+ Channel in Fibroblasts.
Authors: Wu LH; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Department of Basic Medicine Xi'an Medical University Xi'an Shaanxi China., Bai RY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Chen JY; School of Pharmacy Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Pang ZD; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Hai XX; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Han MZ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Yang YY; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Wang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Zhang Y; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Zhang J; School of Pharmacy Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., She G; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Du XJ; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China., Deng XL; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
Source: Journal of the American Heart Association [J Am Heart Assoc] 2026 Apr 07; Vol. 15 (7), pp. e046565. Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101580524 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-9980 (Electronic) Linking ISSN: 20479980 NLM ISO Abbreviation: J Am Heart Assoc Subsets: MEDLINE
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  Data: Dimethyl Fumarate Reverses β-Adrenoceptor-Mediated Myocardial Fibrosis in Mice by Inhibiting Yes-Associated Protein-Regulated Expression of Intermediate-Conductance Ca<superscript>2+</superscript>-Activated K<superscript>+</superscript> Channel in Fibroblasts.
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  Data: <searchLink fieldCode="AU" term="%22Wu+LH%22">Wu LH</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Department of Basic Medicine Xi'an Medical University Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Bai+RY%22">Bai RY</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Chen+JY%22">Chen JY</searchLink>; School of Pharmacy Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Pang+ZD%22">Pang ZD</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Hai+XX%22">Hai XX</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Han+MZ%22">Han MZ</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Yang+YY%22">Yang YY</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Wang+Y%22">Wang Y</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Zhang+J%22">Zhang J</searchLink>; School of Pharmacy Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22She+G%22">She G</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Du+XJ%22">Du XJ</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.<br /><searchLink fieldCode="AU" term="%22Deng+XL%22">Deng XL</searchLink>; Department of Physiology and Pathophysiology, School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
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        Value: 10.1161/JAHA.125.046565
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      – TitleFull: Dimethyl Fumarate Reverses β-Adrenoceptor-Mediated Myocardial Fibrosis in Mice by Inhibiting Yes-Associated Protein-Regulated Expression of Intermediate-Conductance Ca2+-Activated K+ Channel in Fibroblasts.
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