NANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift.

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Title: NANP targeting radiosensitizes glioblastoma through TNFR1 sialylation-driven mesenchymal shift.
Authors: Ding Y; School of Basic Medical Sciences, Institute of Biomedical Innovation, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Provincial Key Laboratory of Tumor Biology, Jiangxi Medical College, Nanchang University, Nanchang, China.; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Zhang ZY; School of Basic Medical Sciences, Institute of Biomedical Innovation, The MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, Provincial Key Laboratory of Tumor Biology, Jiangxi Medical College, Nanchang University, Nanchang, China.; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Ezhilarasan R; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Modrek AS; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.; Department of Radiation Oncology, Keck School of Medicine of University of Southern California (USC), Los Angeles, CA, USA., Graciani M; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Karp J; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., McManus G; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Jambhale A; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA., Sulman EP; Department of Radiation Oncology, New York University (NYU) Grossman School of Medicine, New York, NY, USA. erik.sulman@duke.edu.; Brain and Spine Tumor Center, Laura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA. erik.sulman@duke.edu.; Department of Radiation Oncology, Duke University School of Medicine, Durham, NC, USA. erik.sulman@duke.edu.
Source: Nature communications [Nat Commun] 2026 Mar 18; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2041-1723
DOI:10.1038/s41467-026-70853-x