A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease.

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Title: A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease.
Authors: Saleem T; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany. tayyaba.saleem@med.uni-goettingen.de.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany. tayyaba.saleem@med.uni-goettingen.de., Möbius W; Department of Neurogenetics, Electron Microscopy City Campus, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Schmitz M; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany., da Silva Correia A; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany., Thomas C; Department of Neuropathology, University Medical Center, Göttingen, Germany.; Centre for Neuropathology and Brain Research, Paul-Flechsig Institute, Leipzig, Germany., Canaslan S; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany., Hermann P; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany., Göbel S; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany., Zafar S; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.; Biomedical Engineering and Sciences Department, School of Mechanical and Manufacturing Engineering (SMME), National University of Sciences and Technology (NUST), Islamabad, Pakistan., Root E; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany., Stadelmann C; Department of Neuropathology, University Medical Center, Göttingen, Germany., Andreoletti O; UMR INRA ENVT 1225-Interactions Hôte Agent Pathogène-École Nationale Vétérinaire de Toulouse, Toulouse, France., Hoppert M; Institute of Microbiology and Genetics, Georg-August-University Göttingen, Grisebachstr. 8, 37077, Göttingen, Germany., Fleming Outeiro T; Experimental Neurodegeneration, University Medical Center Göttingen, Waldweg 33, 37073, Göttingen, Germany.; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK., Ferrer I; Emeritus Professor, University of Barcelona, Barcelona, Spain., Younas N; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany. neelam.younas@med.uni-goettingen.de.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany. neelam.younas@med.uni-goettingen.de., Zerr I; Department of Neurology, University Medical Center Göttingen, Robert-Koch-Straße 40, 37075, Göttingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Von-Siebold-Straße 3A, 37075, Göttingen, Germany.
Source: Acta neuropathologica [Acta Neuropathol] 2026 Mar 18; Vol. 151 (1). Date of Electronic Publication: 2026 Mar 18.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0412041 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0533 (Electronic) Linking ISSN: 00016322 NLM ISO Abbreviation: Acta Neuropathol Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1432-0533
DOI:10.1007/s00401-026-02998-4