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Second-line chemotherapy after gemcitabine plus nab-paclitaxel in metastatic pancreatic cancer: comparative outcomes and AI-guided treatment selection.

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Title: Second-line chemotherapy after gemcitabine plus nab-paclitaxel in metastatic pancreatic cancer: comparative outcomes and AI-guided treatment selection.
Authors: Procaccio L; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy., Giordano G; Department of Medical and Surgical Sciences, Policlinico Riuniti di Foggia, Unit of Medical Oncology and Biomolecular Therapy and University of Foggia, Foggia, 71122, Italy., Nichetti F; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy., Milella M; Division of Oncology, Verona University and Hospital Trust (AOUI Verona), Verona, 37126, Italy.; Section of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Verona, 37134, Italy., Pretta A; Medical Oncology, University Hospital and University of Cagliari, Cagliari, 09124, Italy., Iacono D; Department of Oncology, Academic Hospital of Udine ASUFC, Udine, 33100, Italy., Niger M; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy., Casalino S; Investigational Cancer Therapeutics Clinical Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, 37126, Italy., Vivaldi C; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126, Italy.; Unit of Medical Oncology 2, Pisa University Hospital, Pisa, 56124, Italy., De Vita F; Division of Medical Oncology, Department of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, 81100, Italy., Pusceddu V; Medical Oncology, University Hospital and University of Cagliari, Cagliari, 09124, Italy., Landriscina M; Department of Medical and Surgical Sciences, Policlinico Riuniti di Foggia, Unit of Medical Oncology and Biomolecular Therapy and University of Foggia, Foggia, 71122, Italy., Di Paolo G; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy., Sperotto S; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy., Masucci M; Department of Medical and Surgical Sciences, Policlinico Riuniti di Foggia, Unit of Medical Oncology and Biomolecular Therapy and University of Foggia, Foggia, 71122, Italy., Tortora G; Medical Oncology, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00136, Italy.; Medical Oncology, Università Cattolica del Sacro Cuore, Rome, 00168, Italy., Bianco R; Medical Oncology, University of Federico II, Naples, 80138, Italy., Vasile E; Unit of Medical Oncology 2, Pisa University Hospital, Pisa, 56124, Italy., Zaniboni A; Oncology, Fondazione Poliambulanza, Brescia, 25124, Italy., Miceli CC; Division of Medical Oncology, Department of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, 81100, Italy., Ongaro E; Department of Medical Oncology, Centro di Riferimento Oncologico (CRO) IRCCS Aviano, Aviano, 33081, Italy., Giommoni E; Medical Oncology Division, Azienda Ospedaliero-Universitaria Careggi, Firenze, 50134, Italy., Tinè G; Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, 20133, Italy., Barsotti G; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy., Marchesi S; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy., Di Marco M; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, 40126, Italy.; Medical Oncology Unit, IRCSS, Azienda Ospedaliero Universitaria di Bologna, Bologna, 40138, Italy., Ortolani S; Ospedale P. Pederzoli, Casa di cura, Peschiera del Garda, 37019, Italy., Aprile G; Department of Oncology, Academic Hospital of Udine ASUFC, Udine, 33100, Italy., Scartozzi M; Medical Oncology, University Hospital and University of Cagliari, Cagliari, 09124, Italy., Bergamo F; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy., Melisi D; Division of Oncology, Verona University and Hospital Trust (AOUI Verona), Verona, 37126, Italy.; Investigational Cancer Therapeutics Clinical Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, 37126, Italy.; Digestive Molecular and Clinical Oncology Research Unit, University of Verona, Verona, 37129, Italy., Lonardi S; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy.
Source: The oncologist [Oncologist] 2026 Mar 09; Vol. 31 (4).
Publication Type: Journal Article; Observational Study; Comparative Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9607837 Publication Model: Print Cited Medium: Internet ISSN: 1549-490X (Electronic) Linking ISSN: 10837159 NLM ISO Abbreviation: Oncologist Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Second-line chemotherapy after gemcitabine plus nab-paclitaxel in metastatic pancreatic cancer: comparative outcomes and AI-guided treatment selection.
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  Data: <searchLink fieldCode="AU" term="%22Procaccio+L%22">Procaccio L</searchLink>; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy.<br /><searchLink fieldCode="AU" term="%22Giordano+G%22">Giordano G</searchLink>; Department of Medical and Surgical Sciences, Policlinico Riuniti di Foggia, Unit of Medical Oncology and Biomolecular Therapy and University of Foggia, Foggia, 71122, Italy.<br /><searchLink fieldCode="AU" term="%22Nichetti+F%22">Nichetti F</searchLink>; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy.<br /><searchLink fieldCode="AU" term="%22Milella+M%22">Milella M</searchLink>; Division of Oncology, Verona University and Hospital Trust (AOUI Verona), Verona, 37126, Italy.; Section of Innovation Biomedicine-Oncology Area, Department of Engineering for Innovation Medicine (DIMI), University of Verona, Verona, 37134, Italy.<br /><searchLink fieldCode="AU" term="%22Pretta+A%22">Pretta A</searchLink>; Medical Oncology, University Hospital and University of Cagliari, Cagliari, 09124, Italy.<br /><searchLink fieldCode="AU" term="%22Iacono+D%22">Iacono D</searchLink>; Department of Oncology, Academic Hospital of Udine ASUFC, Udine, 33100, Italy.<br /><searchLink fieldCode="AU" term="%22Niger+M%22">Niger M</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Casalino+S%22">Casalino S</searchLink>; Investigational Cancer Therapeutics Clinical Unit, Azienda Ospedaliera Universitaria Integrata Verona, Verona, 37126, Italy.<br /><searchLink fieldCode="AU" term="%22Vivaldi+C%22">Vivaldi C</searchLink>; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, 56126, Italy.; Unit of Medical Oncology 2, Pisa University Hospital, Pisa, 56124, Italy.<br /><searchLink fieldCode="AU" term="%22De+Vita+F%22">De Vita F</searchLink>; Division of Medical Oncology, Department of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, 81100, Italy.<br /><searchLink fieldCode="AU" term="%22Pusceddu+V%22">Pusceddu V</searchLink>; Medical Oncology, University Hospital and University of Cagliari, Cagliari, 09124, Italy.<br /><searchLink fieldCode="AU" term="%22Landriscina+M%22">Landriscina M</searchLink>; Department of Medical and Surgical Sciences, Policlinico Riuniti di Foggia, Unit of Medical Oncology and Biomolecular Therapy and University of Foggia, Foggia, 71122, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Paolo+G%22">Di Paolo G</searchLink>; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy.<br /><searchLink fieldCode="AU" term="%22Sperotto+S%22">Sperotto S</searchLink>; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy.<br /><searchLink fieldCode="AU" term="%22Masucci+M%22">Masucci M</searchLink>; Department of Medical and Surgical Sciences, Policlinico Riuniti di Foggia, Unit of Medical Oncology and Biomolecular Therapy and University of Foggia, Foggia, 71122, Italy.<br /><searchLink fieldCode="AU" term="%22Tortora+G%22">Tortora G</searchLink>; Medical Oncology, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, 00136, Italy.; Medical Oncology, Università Cattolica del Sacro Cuore, Rome, 00168, Italy.<br /><searchLink fieldCode="AU" term="%22Bianco+R%22">Bianco R</searchLink>; Medical Oncology, University of Federico II, Naples, 80138, Italy.<br /><searchLink fieldCode="AU" term="%22Vasile+E%22">Vasile E</searchLink>; Unit of Medical Oncology 2, Pisa University Hospital, Pisa, 56124, Italy.<br /><searchLink fieldCode="AU" term="%22Zaniboni+A%22">Zaniboni A</searchLink>; Oncology, Fondazione Poliambulanza, Brescia, 25124, Italy.<br /><searchLink fieldCode="AU" term="%22Miceli+CC%22">Miceli CC</searchLink>; Division of Medical Oncology, Department of Precision Medicine, University of Campania 'L. Vanvitelli', Naples, 81100, Italy.<br /><searchLink fieldCode="AU" term="%22Ongaro+E%22">Ongaro E</searchLink>; Department of Medical Oncology, Centro di Riferimento Oncologico (CRO) IRCCS Aviano, Aviano, 33081, Italy.<br /><searchLink fieldCode="AU" term="%22Giommoni+E%22">Giommoni E</searchLink>; Medical Oncology Division, Azienda Ospedaliero-Universitaria Careggi, Firenze, 50134, Italy.<br /><searchLink fieldCode="AU" term="%22Tinè+G%22">Tinè G</searchLink>; Biostatistics for Clinical Research Unit, Epidemiology and Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Barsotti+G%22">Barsotti G</searchLink>; Medical Oncology 1, Veneto Institute of Oncology IOV-IRCCS, Padova, 35128, Italy.<br /><searchLink fieldCode="AU" term="%22Marchesi+S%22">Marchesi S</searchLink>; Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, 20133, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Marco+M%22">Di Marco M</searchLink>; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, 40126, Italy.; Medical Oncology Unit, IRCSS, Azienda Ospedaliero Universitaria di Bologna, Bologna, 40138, Italy.<br /><searchLink fieldCode="AU" term="%22Ortolani+S%22">Ortolani S</searchLink>; Ospedale P. 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