Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.
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| Title: | Human DHX29 detects nonoptimal codon usage to regulate mRNA stability. |
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| Authors: | Hia F; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Wu Y; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yoshinaga M; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Goto-Ito S; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Iwasaki W; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Imami K; Proteome Homeostasis Research Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Toh H; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan., Han P; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan., Cai T; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ohira T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Fukao A; Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka, Japan., Standley DM; Department of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan., Shichino Y; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.; Department of RNA Biochemistry, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Takegawa M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Fujiwara T; Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka, Japan., Suzuki T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Iwasaki S; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Bassik MC; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Ito T; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Structural Life Science and Cell Biology Collaboration Team, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Takeuchi O; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan. |
| Source: | Science (New York, N.Y.) [Science] 2026 May 07; Vol. 392 (6798), pp. eadw0288. Date of Electronic Publication: 2026 May 07. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1095-9203 |
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| DOI: | 10.1126/science.adw0288 |
