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Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.

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Title: Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.
Authors: Hia F; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Wu Y; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Yoshinaga M; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Goto-Ito S; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Iwasaki W; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Imami K; Proteome Homeostasis Research Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Toh H; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan., Han P; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan., Cai T; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan., Ohira T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Fukao A; Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka, Japan., Standley DM; Department of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan., Shichino Y; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.; Department of RNA Biochemistry, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Takegawa M; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Fujiwara T; Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka, Japan., Suzuki T; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan., Iwasaki S; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Bassik MC; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Ito T; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Structural Life Science and Cell Biology Collaboration Team, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan., Takeuchi O; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Source: Science (New York, N.Y.) [Science] 2026 May 07; Vol. 392 (6798), pp. eadw0288. Date of Electronic Publication: 2026 May 07.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.
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  Data: <searchLink fieldCode="AU" term="%22Hia+F%22">Hia F</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Wu+Y%22">Wu Y</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Yoshinaga+M%22">Yoshinaga M</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Goto-Ito+S%22">Goto-Ito S</searchLink>; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Iwasaki+W%22">Iwasaki W</searchLink>; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Imami+K%22">Imami K</searchLink>; Proteome Homeostasis Research Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Integrative Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Toh+H%22">Toh H</searchLink>; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Han+P%22">Han P</searchLink>; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Cai+T%22">Cai T</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.<br /><searchLink fieldCode="AU" term="%22Ohira+T%22">Ohira T</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fukao+A%22">Fukao A</searchLink>; Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Standley+DM%22">Standley DM</searchLink>; Department of Genome Informatics, Research Institute for Microbial Diseases, The University of Osaka, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Shichino+Y%22">Shichino Y</searchLink>; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.; Department of RNA Biochemistry, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.<br /><searchLink fieldCode="AU" term="%22Takegawa+M%22">Takegawa M</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Fujiwara+T%22">Fujiwara T</searchLink>; Laboratory of Biochemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+T%22">Suzuki T</searchLink>; Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Iwasaki+S%22">Iwasaki S</searchLink>; RNA Systems Biochemistry Laboratory, Pioneering Research Institute, RIKEN, Wako, Saitama, Japan.; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Bassik+MC%22">Bassik MC</searchLink>; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Ito+T%22">Ito T</searchLink>; Laboratory for Translation Structural Biology, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Structural Life Science and Cell Biology Collaboration Team, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.<br /><searchLink fieldCode="AU" term="%22Takeuchi+O%22">Takeuchi O</searchLink>; Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
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  Data: <searchLink fieldCode="JN" term="%220404511%22">Science (New York, N.Y.)</searchLink> [Science] 2026 May 07; Vol. 392 (6798), pp. eadw0288. <i>Date of Electronic Publication: </i>2026 May 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>0404511 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1095-9203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200368075%22">00368075 </searchLink><i>NLM ISO Abbreviation: </i>Science <i>Subsets: </i>MEDLINE
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