A unique compound 3c targets GSK-3β and metal ion, interferes with tau and metal dyshomeostasis, promotes neurite outgrowth, decreases Aβ accumulation and ABTS•+, and enhances zebrafish motility.
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| Title: | A unique compound 3c targets GSK-3β and metal ion, interferes with tau and metal dyshomeostasis, promotes neurite outgrowth, decreases Aβ accumulation and ABTS•+, and enhances zebrafish motility. |
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| Authors: | Zhang J; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Li Y; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Li YP; Department of Spinal Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Xun QQ; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Ma YY; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China., Shi XL; Medical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, China. Electronic address: sxlmm0924@163.com. |
| Source: | Bioorganic chemistry [Bioorg Chem] 2026 Jun 15; Vol. 174, pp. 109760. Date of Electronic Publication: 2026 Mar 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| ISSN: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2026.109760 |
