Increased VH4+JH6+ antibody heavy chain use in plasmablasts from asymptomatic multiple sclerosis patients.

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Title: Increased VH4+JH6+ antibody heavy chain use in plasmablasts from asymptomatic multiple sclerosis patients.
Authors: Benavides S; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Christley S; School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA., Telesford KM; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Smith C; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Sheffer K; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Wu Y; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Zhang W; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Tse KM; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Greenberg HJ; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Jackson M; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Chapman C; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Dinov D; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Hardeman P; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Siva A; Department of Neurology, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey., Pelletier D; NeuroRX Research, Montreal, QC, Canada., Kantarci O; Neurology, Mayo Clinic, Rochester, MN, USA., Lebrun-Frénay C; Neurology MS Clinic Nice, Pasteur 2 University Hospital; UR2CA-URRIS, Côte d'Azur University, Nice, France., Cowell LG; School of Public Health, UT Southwestern Medical Center, Dallas, TX, USA., Okuda DT; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA., Monson NL; Department of Neurology, UT Southwestern Medical Center, Dallas, TX, USA. nancy.monson@utsouthwestern.edu.; Department of Immunology, UT Southwestern Medical Center, Dallas, TX, USA. nancy.monson@utsouthwestern.edu.
Source: Genes and immunity [Genes Immun] 2026 Jun; Vol. 27 (3), pp. 341-350. Date of Electronic Publication: 2026 Mar 19.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100953417 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5470 (Electronic) Linking ISSN: 14664879 NLM ISO Abbreviation: Genes Immun Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1476-5470
DOI:10.1038/s41435-026-00389-z