Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction.

Saved in:
Bibliographic Details
Title: Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction.
Authors: Sato M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Division of Kumamoto Mouse Clinic (KMC), Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan.; Department of Cardiovascular Medicine, School of Medicine, Saga University, Saga, Japan., Tanabu D; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Torigoe D; Division of Laboratory Animal Science, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan., Kadomatsu T; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Taniwaka K; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.; MitoGenic Co. Ltd., Tokyo, Japan., Ogata Y; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.; MitoGenic Co. Ltd., Tokyo, Japan., Shiiba I; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Suzuki Y; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Ito N; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Inatome R; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Tokuyama T; Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan., Takeiwa T; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Inoue S; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Division of Systems Medicine & Gene Therapy, Faculty of Medicine, Saitama Medical University, Saitama, Japan., Kanai E; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan., Hamano T; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan., Hirata H; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan., Kanamitsu K; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Kusuhara H; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Yokosuka A; Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Mimaki Y; Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Abe H; Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, Tokyo, Japan., Oike Y; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Department of Aging and Geriatric Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp., Yanagi S; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan. shigeru.yanagi@gakushuin.ac.jp.
Source: Npj aging [NPJ Aging] 2026 Mar 20; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:2731-6068
DOI:10.1038/s41514-026-00366-w