Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction.
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| Title: | Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction. |
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| Authors: | Sato M; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Division of Kumamoto Mouse Clinic (KMC), Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan.; Department of Cardiovascular Medicine, School of Medicine, Saga University, Saga, Japan., Tanabu D; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Torigoe D; Division of Laboratory Animal Science, Institute of Resource Developmental and Analysis (IRDA), Kumamoto University, Kumamoto, Japan., Kadomatsu T; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan., Taniwaka K; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.; MitoGenic Co. Ltd., Tokyo, Japan., Ogata Y; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.; MitoGenic Co. Ltd., Tokyo, Japan., Shiiba I; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Suzuki Y; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Ito N; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Inatome R; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan., Tokuyama T; Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan., Takeiwa T; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan., Inoue S; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Division of Systems Medicine & Gene Therapy, Faculty of Medicine, Saitama Medical University, Saitama, Japan., Kanai E; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan., Hamano T; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan., Hirata H; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan., Kanamitsu K; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Kusuhara H; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan., Yokosuka A; Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Mimaki Y; Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan., Abe H; Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, Tokyo, Japan., Oike Y; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Department of Aging and Geriatric Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp., Yanagi S; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan. shigeru.yanagi@gakushuin.ac.jp. |
| Source: | Npj aging [NPJ Aging] 2026 Mar 20; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 20. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Nature Country of Publication: England NLM ID: 9918402285106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2731-6068 (Electronic) Linking ISSN: 27316068 NLM ISO Abbreviation: NPJ Aging Subsets: PubMed not MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41862479 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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Ltd., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ogata+Y%22">Ogata Y</searchLink>; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.; MitoGenic Co. Ltd., Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Shiiba+I%22">Shiiba I</searchLink>; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Suzuki+Y%22">Suzuki Y</searchLink>; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Ito+N%22">Ito N</searchLink>; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Inatome+R%22">Inatome R</searchLink>; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Tokuyama+T%22">Tokuyama T</searchLink>; Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Medical University, Tochigi, Japan.; Division of Functional Biochemistry, Department of Biochemistry, Jichi Medical University, Tochigi, Japan.<br /><searchLink fieldCode="AU" term="%22Takeiwa+T%22">Takeiwa T</searchLink>; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Inoue+S%22">Inoue S</searchLink>; Department of Systems Aging Science and Medicine, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.; Division of Systems Medicine & Gene Therapy, Faculty of Medicine, Saitama Medical University, Saitama, Japan.<br /><searchLink fieldCode="AU" term="%22Kanai+E%22">Kanai E</searchLink>; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Hamano+T%22">Hamano T</searchLink>; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Hirata+H%22">Hirata H</searchLink>; Department of Chemistry and Biological Science, College of Science and Engineering, Aoyama Gakuin University, Sagamihara, Japan.<br /><searchLink fieldCode="AU" term="%22Kanamitsu+K%22">Kanamitsu K</searchLink>; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Kusuhara+H%22">Kusuhara H</searchLink>; Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Yokosuka+A%22">Yokosuka A</searchLink>; Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Mimaki+Y%22">Mimaki Y</searchLink>; Department of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Abe+H%22">Abe H</searchLink>; Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University, Tokyo, Japan.<br /><searchLink fieldCode="AU" term="%22Oike+Y%22">Oike Y</searchLink>; Department of Molecular Genetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Center for Metabolic Regulation of Healthy Aging (CMHA), Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.; Department of Aging and Geriatric Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. oike@gpo.kumamoto-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Yanagi+S%22">Yanagi S</searchLink>; Laboratory of Molecular Biochemistry, Department of Life Science, Faculty of Science, Gakushuin University, Tokyo, Japan. shigeru.yanagi@gakushuin.ac.jp. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229918402285106676%22">Npj aging</searchLink> [NPJ Aging] 2026 Mar 20; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Mar 20. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer+Nature%22">Springer Nature </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9918402285106676 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2731-6068 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2227316068%22">27316068 </searchLink><i>NLM ISO Abbreviation: </i>NPJ Aging <i>Subsets: </i>PubMed not MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41862479 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/s41514-026-00366-w Languages: – Code: eng Text: English Titles: – TitleFull: Mitorubin, berberrubine-based compounds that improve mitochondrial function, exhibit cardioprotective effects against age-related cardiac dysfunction. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sato M – PersonEntity: Name: NameFull: Tanabu D – PersonEntity: Name: NameFull: Torigoe D – PersonEntity: Name: NameFull: Kadomatsu T – PersonEntity: Name: NameFull: Taniwaka K – PersonEntity: Name: NameFull: Ogata Y – PersonEntity: Name: NameFull: Shiiba I – PersonEntity: Name: NameFull: Suzuki Y – PersonEntity: Name: NameFull: Ito N – PersonEntity: Name: NameFull: Inatome R – PersonEntity: Name: NameFull: Tokuyama T – PersonEntity: Name: NameFull: Takeiwa T – PersonEntity: Name: NameFull: Inoue S – PersonEntity: Name: NameFull: Kanai E – PersonEntity: Name: NameFull: Hamano T – PersonEntity: Name: NameFull: Hirata H – PersonEntity: Name: NameFull: Kanamitsu K – PersonEntity: Name: NameFull: Kusuhara H – PersonEntity: Name: NameFull: Yokosuka A – PersonEntity: Name: NameFull: Mimaki Y – PersonEntity: Name: NameFull: Abe H – PersonEntity: Name: NameFull: Oike Y – PersonEntity: Name: NameFull: Yanagi S IsPartOfRelationships: – BibEntity: Dates: – D: 20 M: 03 Text: 2026 Mar 20 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 2731-6068 Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: Npj aging Type: main |
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