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A multi-ancestry genome-wide study of tamoxifen metabolism and breast cancer recurrence.

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Title: A multi-ancestry genome-wide study of tamoxifen metabolism and breast cancer recurrence.
Authors: Khor CC; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, Singapore, 138672, Singapore.; Singapore Eye Research Institute, Singapore, Singapore.; SingHealth and Duke-NUS Ophthalmology & Visual Sciences Academic Clinical Programme (EYE ACP), SingHealth Duke-NUS Academic Medical Centre, Singapore, Singapore., Ong WS; Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre Singapore, Singapore, Singapore., Lim EH; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Chatelut E; Univ Toulouse, Inserm, CRCT, Toulouse, France.; Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France., Chen S; Clinical Pharmacology Laboratory, Division of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, Singapore., Muerdter TE; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tuebingen, Tuebingen, Germany., Abraham JE; Department of Oncology (Box 193), Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Cambridge Experimental Cancer Medicine Centre and Cancer Research UK Cambridge Centre, Cambridge, UK.; Cambridge Breast Cancer Research Unit, NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK., Sutiman N; Clinical Pharmacology Laboratory, Division of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, Singapore., Lim JSL; Clinical Pharmacology Laboratory, Division of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, Singapore., Lee SS; Clinical Pharmacology Laboratory, Division of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, Singapore., Arellano C; Univ Toulouse, Inserm, CRCT, Toulouse, France., Li Z; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, Singapore, 138672, Singapore., Sim KS; Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome, Singapore, 138672, Singapore., Eccles DM; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Tapper WJ; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Maishman T; Faculty of Medicine, Cancer Sciences Academic Unit and University of Southampton Clinical Trials Unit, University of Southampton, Southampton, UK.; University Hospital Southampton NHS Foundation Trust, Southampton, UK., Zgheib NK; Faculty of Medicine, Department of Pharmacology and Toxicology, American University of Beirut, Beirut, Lebanon., Winter S; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tuebingen, Tuebingen, Germany., Ganchev B; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tuebingen, Tuebingen, Germany., Dorling L; Centre for Cancer Genetic Epidemiology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK., Guo Q; Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK., Caldas C; Department of Oncology (Box 193), Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Cambridge Breast Cancer Research Unit, NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Earl HM; Department of Oncology (Box 193), Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Cambridge Experimental Cancer Medicine Centre and Cancer Research UK Cambridge Centre, Cambridge, UK.; Cambridge Breast Cancer Research Unit, NIHR Cambridge Biomedical Research Centre, Cambridge University Hospital NHS Foundation Trust, Cambridge, UK., Hiller L; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Dunn J; Warwick Clinical Trials Unit, University of Warwick, Coventry, UK., Ng RCH; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Yap YS; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Wong M; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Wong FY; Division of Radiation Oncology, National Cancer Centre Singapore, Singapore, Singapore., Wong NS; OncoCare Cancer Centre, Mount Elizabeth Novena Medical Centre, Singapore, Singapore., Ang PCS; OncoCare Cancer Centre, Mount Elizabeth Novena Medical Centre, Singapore, Singapore., Dent R; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore., Krippl P; Department of Internal Medicine, General Hospital Furstenfeld, Furstenfeld, Austria., Langsenlehner U; Internal Outpatient Department, Medizinische Universitat Graz, Graz, Austria., Langsenlehner T; Internal Outpatient Department, Medizinische Universitat Graz, Graz, Austria., Tfayli A; Hematology-Oncology Division, Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon., Schaeffeler E; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tuebingen, Tuebingen, Germany., Eichelbaum M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tuebingen, Tuebingen, Germany., Hamann U; Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Fasching PA; University Breast Centre Franconia & University Hospital Erlangen, Erlangen, Germany., Beckmann MW; Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlanger-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany., Dalenc F; Univ Toulouse, Inserm, CRCT, Toulouse, France.; Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France., White-Koning M; Univ Toulouse, Inserm, CRCT, Toulouse, France., Brauch HB; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner Site Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany., Schroth W; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; University Tuebingen, Tuebingen, Germany., Renner W; Clinical Institute of Medical and Laboratory Diagnostics, Medical University Graz, Graz, Austria., Schwab M; Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Partner Site Tübingen, Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', University of Tübingen, Tübingen, Germany.; Departments of Clinical Pharmacology and Biochemistry and Pharmacy, University of Tübingen, Tübingen, Germany., Thomas F; Univ Toulouse, Inserm, CRCT, Toulouse, France.; Institut Claudius Regaud, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France., Chowbay B; Clinical Pharmacology Laboratory, Division of Cellular & Molecular Research, National Cancer Centre Singapore, Singapore, Singapore. ctebal@nccs.com.sg.; Centre for Clinician-Scientist Development, Duke-NUS Medical School, Singapore, Singapore. ctebal@nccs.com.sg.
Source: NPJ breast cancer [NPJ Breast Cancer] 2026 Mar 20; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 20.
Publication Type: Journal Article
Journal Info: Publisher: Breast Cancer Research Foundation Country of Publication: United States NLM ID: 101674891 Publication Model: Electronic Cited Medium: Print ISSN: 2374-4677 (Print) Linking ISSN: 23744677 NLM ISO Abbreviation: NPJ Breast Cancer Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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Description
ISSN:2374-4677
DOI:10.1038/s41523-026-00931-2