Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons.

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Title: Targeting p75NTR activity alleviates the neurotoxic effect of high glucose on iPSC-derived dopaminergic neurons.
Authors: Chanoumidou K; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece. konstantina_chanoumidou@imbb.forth.gr.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece. konstantina_chanoumidou@imbb.forth.gr., Zota I; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Papadopoulou MA; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Konstantinou C; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Tsimpolis A; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Tsagliotis E; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Tziortziou M; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4362, Esch-sur-Alzette, Luxembourg., Ntarntani K; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece., Grünewald A; Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 4362, Esch-sur-Alzette, Luxembourg., Lavigne MD; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Gravanis A; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece., Charalampopoulos I; Department of Pharmacology, Medical School, University of Crete, 71003, Heraklion, Greece. charalampn@uoc.gr.; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 71003, Heraklion, Greece. charalampn@uoc.gr.
Source: Stem cell research & therapy [Stem Cell Res Ther] 2026 Mar 21; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 21.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101527581 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-6512 (Electronic) Linking ISSN: 17576512 NLM ISO Abbreviation: Stem Cell Res Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1757-6512
DOI:10.1186/s13287-026-04965-y