Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026.

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Title: Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Sepsis and Septic Shock in Children 2026.
Authors: Weiss SL; Division of Critical Care, Department of Pediatrics, Nemours Children's Hospital, Wilmington, DE.; Department of Pediatrics and Pathology, Anatomy, & Cell Biology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA., Peters MJ; Infection, Immunity and Inflammation Department, UCL Great Ormond St Institute of Child Health, London, United Kingdom.; Paediatric Intensive Care Unit, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom., Oczkowski SJW; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Belley-Cote E; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.; Divisions of Cardiology and Critical Care, McMaster University, Hamilton, ON, Canada., Buysse C; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Choong KLM; Department of Medicine, McMaster University, Hamilton, ON, Canada., Deep A; Paediatric Intensive Care Unit, King's College Hospital NHS Foundation Trust, London, United Kingdom., Inwald DP; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Flori HR; Division of Pediatric Critical Care, Department of Pediatrics, University of Michigan, Ann Arbor, MI., Kneyber MCJ; Department of Paediatrics, Division of Paediatric Critical Care Medicine, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands.; Critical care, Anaesthesiology, Peri-operative & Emergency medicine (CAPE), University of Groningen, Groningen, The Netherlands., Menon K; Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada.; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada., Murthy S; Critical Care, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada., Nunnally ME; Department of Anesthesiology, New York University, New York, NY., Parker MM; Department of Pediatrics, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY., Schlapbach LJ; Department of Intensive Care and Neonatology, University Children`s Hospital Zurich, University of Zurich, Zurich, Switzerland.; Child Health Research Centre, The University of Queensland, Brisbane, QLD, Australia., Oliveira CF; Latin American Sepsis Institute, São Paulo, Brazil.; Associação de Medicina Intensiva Brasileira-AMIB, São Paulo, Brazil., Sorce LR; Department of Nursing, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.; Division of Pediatric Critical Care, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL., Agus M; Division of Medical Critical Care, Department of Pediatrics, Boston Children's Hospital, Boston, MA.; Harvard Medical School, Boston, MA., Argent AC; Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa., Balamuth F; Division of Emergency Medicine, Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Bansal A; Division of Pediatric Critical Care, Advance Pediatric Center, PGIMER, Chandigarh, India., Bem RA; Pediatric Intensive Care Unit, Emma Children's Hospital, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Research Institute, Amsterdam UMC, Amsterdam, The Netherlands., Brierley J; Paediatric Intensive Care Unit, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom., Burns KEA; Unity Health Toronto-St. Michael's Hospital, Toronto, ON, Canada.; Interdepartmental Division of Critical Care, University of Toronto, Toronto, ON, Canada.; Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, ON, Canada., Carlton EF; Division of Pediatric Critical Care, Department of Pediatrics, University of Michigan, Ann Arbor, MI.; Susan B. Meister Child Health Evaluation and Research Center, Department of Pediatrics, University of Michigan, Ann Arbor, MI., Carrol ED; Department of Clinical Infection, Microbiology and Immunology, University of Liverpool Institute of Infection, Veterinary and Ecological Sciences, Liverpool, United Kingdom., Carroll CL; Division of Pediatric Critical Care, Department of Pediatrics, UF College of Medicine Jacksonville, Jacksonville, FL., Carter MJ; Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.; Paediatric Critical Care Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Conlon TW; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Anesthesiology, Critical Care, and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Daniels R; University of South Carolina, College of Pharmacy, Columbia, SC., De Luca D; Division of Pediatrics and Neonatal Critical Care, APHP-Paris Saclay University, 'A.Beclere' Medical Centre, Paris, France.; Physiopathology and Therapeutic Innovation Unit, INSERM U998, Paris-Saclay University, Orsay, France., Di Nardo M; Pediatric Intensive Care Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy., Dulfer K; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands.; Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Faust SN; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.; NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom., Fernandez-Sarmiento J; Department of Pediatrics and Intensive Care, Universidad de La Sabana, Chía, Colombia.; Department of Pediatrics and Intensive Care, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá, Colombia., Fitzgerald JC; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Anesthesiology, Critical Care, and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Hall M; Division of Critical Care Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH.; Nationwide Children's Hospital, Columbus, OH., Hsu BS; Division of Pediatric Critical Care, Department of Pediatrics, University of South Dakota Sanford School of Medicine, Sioux Falls, SD., Javouhey E; Pediatric Critical Care Unit, Hospices Civils de Lyon, Lyon, France.; University Lyon1, Lyon, France., Joosten K; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, The Netherlands., Karam O; Pediatric Critical Care Medicine, Department of Pediatrics, Yale School of Medicine, New Haven, CT., Kelly SP; Pediatric Critical Care, Department of Pediatrics, Doernbecher Children's Hospital Oregon Health & Science University, Portland, OR., Lang HJ; Heidelberg Institute of Global Health, Heidelberg, Germany.; NGO Alliance for International Medical Action, Dakar, Sénégal., Lee JH; Children's Intensive Care Unit, KK Women's and Children's Hospital, Singapore.; Singhealth-DukeNUS Paediatrics Academic Clinical Programme, Duke-NUS Medical School, Singapore., Lemson J; Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., MacLaren G; Cardiothoracic ICU, National University Hospital, Singapore., Manning JC; Division of Nursing Science, Pregnancy and Child Health, School of Healthcare, College of Life Sciences, University of Leicester, Leicester, United Kingdom.; Nottingham Children's Hospital, Family Health Clinical Care Group, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom., Mehta N; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA., Morin L; IHU-SEPSIS Comprehensive Sepsis Centre, Pediatric and Neonatal Intensive Care Unit, AP-HP Paris Saclay University, Le Kremlin-Bicêtre, France.; Medical School, Paris Saclay University, Le Kremlin-Bicêtre, France.; Institute of Integrative Biology of the Cell, CNRS, CEA, Paris Saclay University, Gif-sur-Yvette, France., Morrow BM; Department of Paediatrics and Child Health, University of Cape Town, Cape Town, South Africa., Nadel S; Paediatric Intensive Care, St Mary's Hospital, London, United Kingdom.; Paediatrics, Imperial College London, London, United Kingdom.; Centre for Paediatrics and Child Health, Imperial College London, London, United Kingdom., Nishisaki A; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Anesthesiology, Critical Care, and Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Pong S; The Hospital for Sick Children, Toronto, ON, Canada., Raman S; Children's Intensive Care Research Program, Children Health Research Centre, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, QLD, Australia.; Paediatric Intensive Care, Queensland Children's Hospital, Brisbane, QLD, Australia., Randolph AG; Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston, MA.; Departments of Anaesthesia and Pediatrics, Harvard Medical School, Boston, MA., Ranjit S; Pediatric ICU, Apollo Children's Hospital, Chennai, India., Ray S; Paediatric Intensive Care Unit, Great Ormond Street Hospital NHS Foundation Trust, London, United Kingdom.; Infection, Inflammation and Immunity Teaching and Research Division, UCL GOS Institute of Child Health, London, United Kingdom., Remy KE; Internal Medicine, Pulmonary Critical Care Medicine, Case Western School of Medicine, Cleveland, OH.; Pediatrics, Critical Care Medicine, Case Western School of Medicine, Cleveland, OH.; CWRU-University Hospitals of Cleveland Blood, Heart, Lung & Immunology Research Center, Cleveland, OH., Scott HF; Department of Pediatrics, Section of Pediatric Emergency Medicine, University of Colorado School of Medicine, Aurora, CO., Sick-Samuels AC; Pediatric Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD.; Associate Hospital Epidemiologist, Johns Hopkins Hospital, Baltimore, MD., Souza DC; Latin American Sepsis Institute, São Paulo, Brazil.; Pediatric Intensive Care Unit, Hospital Universitario, Universidade de São Paulo, São Paulo, Brazil.; Pediatric Critical Care Unit, Hospital Sitio Libanês, São Paulo, Brazil., Swan T; Pediatric Emergency Department, AdventHealth Ocala, Ocala, FL., Tibby SM; Department of Paediatric Intensive Care, Evelina London Children's Hospital, London, United Kingdom.; Department of Women and Children's Health, Kings College London, United Kingdom., Valla FV; Nutrition Support Team, Hospices Civils de Lyon, Lyon, France., Watson RS; Department of Pediatrics, University of Washington, Seattle, WA.; Pediatric Critical Care Medicine, Seattle Children's Hospital, Seattle, WA.; Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, WA., Wiens MO; Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.; Walimu, Kampala, Uganda., Wolf J; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN.; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN., Zimmerman JJ; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA., Tissieres P; IHU-SEPSIS Comprehensive Sepsis Centre, Pediatric and Neonatal Intensive Care Unit, AP-HP Paris Saclay University, Le Kremlin-Bicêtre, France.; Medical School, Paris Saclay University, Le Kremlin-Bicêtre, France.; Institute of Integrative Biology of the Cell, CNRS, CEA, Paris Saclay University, Gif-sur-Yvette, France., Kissoon N; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Source: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies [Pediatr Crit Care Med] 2026 Apr 01; Vol. 27 (4), pp. 494-513. Date of Electronic Publication: 2026 Mar 23.
Publication Type: Journal Article
Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 100954653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-7535 (Print) Linking ISSN: 15297535 NLM ISO Abbreviation: Pediatr Crit Care Med Subsets: MEDLINE; In Process
Database: MEDLINE Ultimate
Description
ISSN:1529-7535
DOI:10.1097/PCC.0000000000003928