Deep learning-guided dual-fitness evolution of T7 RNA polymerase for enhanced stability and activity.
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| Title: | Deep learning-guided dual-fitness evolution of T7 RNA polymerase for enhanced stability and activity. |
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| Authors: | Jiang F; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China., Kang L; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China., Li M; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China., Zhong B; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China., Chen X; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China., Wu B; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China., Li M; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China., Yu Y; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China., Hong L; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; Shanghai National Centre for Applied Mathematics (SJTU Center), MOE-LSC, Shanghai Jiao Tong University, Shanghai 200240, China.; Shanghai Artificial Intelligence Laboratory, Shanghai 200232, China. |
| Source: | Nucleic acids research [Nucleic Acids Res] 2026 Mar 19; Vol. 54 (6). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1362-4962 |
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| DOI: | 10.1093/nar/gkag259 |
