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Deep learning-guided dual-fitness evolution of T7 RNA polymerase for enhanced stability and activity.

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Title: Deep learning-guided dual-fitness evolution of T7 RNA polymerase for enhanced stability and activity.
Authors: Jiang F; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China., Kang L; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China., Li M; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China., Zhong B; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China., Chen X; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China., Wu B; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China., Li M; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China., Yu Y; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China., Hong L; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; Shanghai National Centre for Applied Mathematics (SJTU Center), MOE-LSC, Shanghai Jiao Tong University, Shanghai 200240, China.; Shanghai Artificial Intelligence Laboratory, Shanghai 200232, China.
Source: Nucleic acids research [Nucleic Acids Res] 2026 Mar 19; Vol. 54 (6).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Jiang+F%22">Jiang F</searchLink>; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Kang+L%22">Kang L</searchLink>; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhong+B%22">Zhong B</searchLink>; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China.<br /><searchLink fieldCode="AU" term="%22Li+M%22">Li M</searchLink>; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.<br /><searchLink fieldCode="AU" term="%22Yu+Y%22">Yu Y</searchLink>; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Hong+L%22">Hong L</searchLink>; Institute of Natural Sciences & School of Physics and Astronomy, Shanghai Jiao Tong University, Shanghai 200240, China.; Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai 201203, China.; Shanghai National Centre for Applied Mathematics (SJTU Center), MOE-LSC, Shanghai Jiao Tong University, Shanghai 200240, China.; Shanghai Artificial Intelligence Laboratory, Shanghai 200232, China.
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        Value: 10.1093/nar/gkag259
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              Text: 2026 Mar 19
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