A novel humanized immune stroma PDX cancer model for therapeutic studies.

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Title: A novel humanized immune stroma PDX cancer model for therapeutic studies.
Authors: Yang D; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UPMC Hillman Cancer Center and the Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Beddows I; Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA., Tang H; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UPMC Hillman Cancer Center and the Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA., Bai S; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UPMC Hillman Cancer Center and the Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA., Cascio S; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UPMC Hillman Cancer Center and the Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., McGonigal SC; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UPMC Hillman Cancer Center and the Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA., Johnson BK; Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA., Powers JJ; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Acharya R; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Bao R; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; UPMC Hillman Cancer Center, Pittsburgh, PA, USA., Bruno TC; UPMC Hillman Cancer Center, Pittsburgh, PA, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, USA., Soong TR; Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, USA., Conejo-Garcia JR; Department of Immunology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Shen H; Department of Epigenetics, Van Andel Research Institute, Grand Rapids, MI, USA., Bility MT; Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Buckanovich RJ; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, UPMC Hillman Cancer Center and the Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA. buckanovichrj@mwri.magee.edu.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. buckanovichrj@mwri.magee.edu.
Source: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2026 Mar 24; Vol. 75 (4). Date of Electronic Publication: 2026 Mar 24.
Publication Type: Journal Article
Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8605732 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0851 (Electronic) Linking ISSN: 03407004 NLM ISO Abbreviation: Cancer Immunol Immunother Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1432-0851
DOI:10.1007/s00262-026-04349-4