HMGB1 reduce DNA damage by binding KU70 to activate NHEJ pathway in colorectal cancer cells after radiation.

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Title: HMGB1 reduce DNA damage by binding KU70 to activate NHEJ pathway in colorectal cancer cells after radiation.
Authors: Liu X; Department of Immunology, Binzhou Medical University, Yantai, Shandong, China., Han Y; Department of Immunology, Binzhou Medical University, Yantai, Shandong, China.; Department of Biochemistry and Molecular Biology, School of Life Sciences, Shandong Agricultural University, Taian, Shandong, China., Kuang R; Department of Immunology, Binzhou Medical University, Yantai, Shandong, China., Sheng W; Department of Radiation therapy, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, Shandong, China., Zhang Y; Department of Clinical Laboratory, Yantaishan Hospital Affiliated to Binzhou Medical University, Yantai, Shandong, China., Jia X; Department of Immunology, Binzhou Medical University, Yantai, Shandong, China., Gao X; Department of Immunology, Binzhou Medical University, Yantai, Shandong, China., Ma Y; Department of Immunology, Binzhou Medical University, Yantai, Shandong, China.
Source: PloS one [PLoS One] 2026 Mar 24; Vol. 21 (3), pp. e0345635. Date of Electronic Publication: 2026 Mar 24 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database: MEDLINE Ultimate
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ISSN:1932-6203
DOI:10.1371/journal.pone.0345635